The bilateral Left Cerebrum.Occipital Lobe.Lingual Gyrus, as defined in the Talairach 1 mm atlas, corresponds to a medial occipitotemporal cortical region running along the ventral surface of the occipital lobe, bordering the calcarine sulcus and extending anteriorly toward the fusiform gyrus. It is primarily involved in early and intermediate stages of visual processing, including analysis of complex shapes, letters, and word forms, as well as aspects of color, scene perception, and visual memory. Functional imaging studies associate this gyrus with visual word recognition, encoding of visual context, and contributions to higher-order visuospatial processing, often in concert with adjacent calcarine and fusiform regions. No direct link exists for the Talairach-specific label, but the region is encompassed within the Lingual gyrus.
The bilateral lingual gyrus in the occipital lobe (Talairach Left Cerebrum.Occipital Lobe.Lingual Gyrus) has been repeatedly implicated in genetic studies of visual processing, reading, and neuropsychiatric and neurodegenerative disorders. GWAS and imaging‑genetics work indicate that common variants in genes involved in synaptic plasticity, neurodevelopment, and myelination (for example, BDNF, NRG1, DISC1, and several MHC-region loci) modulate lingual gyrus volume, cortical thickness, functional activation, or connectivity, particularly in tasks involving visual word recognition, face and scene processing, and emotional visual stimuli. Polygenic risk for schizophrenia, major depressive disorder, bipolar disorder, and autism has been associated with altered morphology or functional responses in the lingual gyrus, and APOE ε4 and other Alzheimer’s disease risk variants show correlations with atrophy or hypometabolism in occipital/lingual regions in some cohorts. GWAS of educational attainment, reading ability/dyslexia, and general cognitive performance have also reported associations with structural or functional variation in the lingual gyrus, suggesting genetically influenced contributions to literacy and higher-order vision. Additionally, migraine and visual aura–related genetic risk loci (e.g., in ion-channel and glutamatergic genes such as CACNA1A and GRIN family members) have been linked to altered occipital and lingual gyrus responses, consistent with a genetic basis for individual differences in visual cortex excitability and susceptibility to visual disturbances.
Overview generated by GPT-4o (2026).
Region ID: 238
Hemisphere: bilateral
Atlas: Talairach labels 1mm
Full Quality Version: Download MP4
Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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