The bilateral Left Cerebrum.Parietal Lobe.Postcentral Gyrus.Gray Matter.Brodmann area 5 corresponds to a portion of the superior parietal lobule located just posterior to the primary somatosensory cortex (Brodmann areas 3, 1, and 2) in the postcentral gyrus. This region participates in higher-order somatosensory processing, integrating tactile, proprioceptive, and kinesthetic information to support complex body schema representation, spatial awareness, and sensorimotor coordination. Neurons in Brodmann area 5 receive convergent input from primary somatosensory areas and project to other parietal and frontal regions, contributing to functions such as object manipulation, guidance of limb movements, and integration of sensory input with motor plans. There is no direct link for this exact Talairach label; a closely related structure is Brodmann area 5.
The bilateral left parietal postcentral gyrus gray matter in Brodmann area 5, a higher-order somatosensory association region implicated in tactile integration, proprioception, and sensorimotor coordination, has been indirectly linked to genetic variation through imaging-genetics and GWAS of cortical morphology, somatosensory function, and related neuropsychiatric traits. Large-scale cortical surface–based GWAS (e.g., ENIGMA and related consortia) have identified common variants in genes involved in neurodevelopment, axon guidance, and synaptic signaling—such as MIR137, HMGA2, Microtubule-/cell-adhesion–related genes, and multiple loci near Wnt and MAPK pathway genes—that associate with parietal cortical thickness, surface area, or gyrification, often including or overlapping the postcentral gyrus. Polygenic architectures for schizophrenia, autism spectrum disorder, ADHD, and major depression show associations with structural alterations in the superior and inferior parietal lobule and postcentral regions, suggesting shared genetic influences on parietal association cortex development. Variants in genes such as CNTNAP2, NRGN, and other synaptic or neurodevelopmental genes have been tied to altered parietal activation and structure in tasks involving sensory integration and attention, while GWAS of somatosensory phenotypes (e.g., chronic pain, tactile sensitivity) and body perception sometimes implicate parietal loci that map onto or near area 5. However, no single gene or variant is uniquely specific to BA5 in the Talairach 1 mm atlas; rather, this region reflects a convergence of polygenic influences on parietal lobe structure and function, with genetic effects typically distributed across broader parietal and frontoparietal networks.
Overview generated by GPT-4o (2026).
Region ID: 1095
Hemisphere: bilateral
Atlas: Talairach labels 1mm
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Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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