Bilateral Left Cerebrum.Sub-lobar.Extra-Nuclear.Gray Matter.Brodmann area 47 refers to the gray matter of Brodmann area 47 located in the sub-lobar region of the left cerebral hemisphere, encompassing parts of the ventrolateral prefrontal cortex, particularly within the inferior frontal gyrus. This area is implicated in higher-order cognitive functions including semantic processing, language comprehension and production, emotional evaluation of stimuli, and aspects of decision-making involving reward and affective valence. Brodmann area 47 participates in fronto-temporal networks supporting complex social cognition and integrative processing of auditory and visual information, and is often grouped within the orbitofrontal and ventrolateral prefrontal cortices. Brodmann area 47
Brodmann area 47 (inferior frontal gyrus/orbitofrontal cortex within the sub-lobar extra-nuclear gray matter of the left cerebrum) has been implicated in multiple genetic and genome-wide association studies, primarily through imaging-genetics and neuropsychiatric research. Structural and functional variation in this region has been associated with common variants in genes involved in synaptic function, cortical development, and neurotransmission, including but not limited to CACNA1C, DISC1, BDNF, COMT, and ZNF804A, which show effects on prefrontal/orbitofrontal volume, cortical thickness, or activation patterns. Large-scale imaging GWAS (e.g., ENIGMA and UK Biobank) have linked polygenic risk scores for schizophrenia, bipolar disorder, major depressive disorder, and autism spectrum disorder to alterations in inferior frontal/orbitofrontal morphology encompassing BA47, while alcohol and nicotine use GWAS highlight this region within fronto-striatal reward and impulse-control circuits. BA47 is also frequently implicated in genetic studies of language and semantic processing, with FOXP2-related pathways and other language-associated loci influencing inferior frontal activation, and in GWAS of personality and cognitive traits (e.g., neuroticism, impulsivity, executive function) that show correlational overlap with BA47 structure and connectivity, suggesting a genetically influenced role in affect regulation, social cognition, and decision-making.
Overview generated by GPT-4o (2026).
Region ID: 511
Hemisphere: bilateral
Atlas: Talairach labels 1mm
Full Quality Version: Download MP4
Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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