The bilateral Right Cerebrum.Frontal Lobe.Gray Matter.Brodmann area 10 corresponds to the most anterior portion of the prefrontal cortex, often termed the frontopolar cortex, located in the frontal pole of the right hemisphere and extending across the midline to its left-hemisphere homologue in a Talairach 1 mm atlas framework. This region is cytoarchitectonically defined by its distinctive granular frontal cortex organization and is implicated in high-level integrative functions, including prospective memory, complex decision-making, multitasking, and the coordination of internally generated thoughts with external demands. Brodmann area 10 is also associated with aspects of social cognition and abstract reasoning, making it a key node within large-scale networks supporting executive control and default-mode operations. Brodmann area 10
Brodmann area 10 (frontopolar prefrontal cortex) in the bilateral right frontal lobe has been implicated in multiple genetic and GWAS findings, particularly in relation to higher-order cognition, psychiatric risk, and brain structural variation. Imaging–genetics and large-scale GWAS of cortical thickness and surface area (e.g., ENIGMA, UK Biobank) consistently identify common variants in neurodevelopmental and synaptic genes—such as those in the MAPT locus on 17q21, HMGA2, and genes involved in Wnt and neuronal differentiation pathways—as influencing gray-matter morphology in frontopolar and adjacent prefrontal regions, including right BA10. Polygenic risk scores for schizophrenia, bipolar disorder, major depressive disorder, and autism spectrum conditions often correlate with altered volume or cortical thickness in this area, aligning with case–control MRI studies that report BA10 abnormalities in these disorders. GWAS of general cognitive ability, educational attainment, and executive function show enrichment of genetic variants that also relate to prefrontal cortical structure, with BA10 frequently highlighted as part of a frontoparietal network mediating abstract reasoning, prospective memory, and mentalizing. Additionally, genetic risk loci for neurodegenerative and neurodevelopmental conditions (e.g., Alzheimer’s disease, frontotemporal dementia, ADHD) have been associated with subtle structural and functional variation in right frontopolar cortex, suggesting that BA10 serves as a convergence zone where polygenic influences on cognition, psychiatric liability, and brain aging manifest at the anatomical level.
Overview generated by GPT-4o (2026).
Region ID: 471
Hemisphere: bilateral
Atlas: Talairach labels 1mm
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Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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