The bilateral Right Cerebrum.Frontal Lobe.Inferior Frontal Gyrus.Gray Matter.Brodmann area 47 corresponds to a ventrolateral prefrontal cortical region located in the orbital and ventral parts of the inferior frontal gyrus, adjacent to the anterior temporal lobe. Brodmann area 47 is implicated in higher-order cognitive processes including language semantics, controlled retrieval of memory, evaluation of reward and punishment, and aspects of social and emotional decision-making. It receives multimodal sensory inputs and is strongly interconnected with limbic structures (such as the amygdala) and other prefrontal areas, supporting its role in integrating affective and contextual information for flexible behavioral control, particularly in the right hemisphere where it is often linked to emotional and social cognition. Brodmann area 47
The inferior frontal gyrus (IFG) in Brodmann area 47, a ventrolateral prefrontal region implicated in language, social cognition, and inhibitory control, has been repeatedly linked in imaging–genetics and GWAS-based imaging studies to variants in genes affecting synaptic plasticity, neurotransmission, and neurodevelopment, including associations of gray matter volume and cortical thickness with common polymorphisms in BDNF (e.g., Val66Met), COMT (e.g., Val158Met), and genes in dopaminergic and glutamatergic pathways; large-scale imaging GWAS consortia such as ENIGMA and UK Biobank have identified SNPs in loci including MIR137, CACNA1C, GRIN2B, and other calcium-channel and synaptic genes that show effects on prefrontal morphology and function encompassing BA47, while polygenic risk scores for schizophrenia, major depressive disorder, bipolar disorder, and autism spectrum disorder have been associated with structural and functional alterations in this region. BA47/IFG has also appeared in genetic studies of traits such as impulsivity, response inhibition, language and reading ability (including links to FOXP2 and dyslexia-related loci), and risk-taking, where genetic variants that influence frontal-striatal and frontal-temporal circuitry modulate activation or gray matter measures in BA47 during tasks involving semantic processing, emotional regulation, and cognitive control, although findings are typically distributed across broader prefrontal networks rather than being uniquely specific to this Talairach-defined region.
Overview generated by GPT-4o (2026).
Region ID: 188
Hemisphere: bilateral
Atlas: Talairach labels 1mm
Full Quality Version: Download MP4
Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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