The bilateral Right Cerebrum.Frontal Lobe.Medial Frontal Gyrus.Gray Matter.Brodmann area 11 corresponds to a ventromedial segment of the prefrontal cortex located on the basal and medial surfaces of the frontal lobe, anterior to the orbitofrontal cortex and superior to the gyrus rectus. Cytoarchitectonically, Brodmann area 11 is characterized by a granular prefrontal lamination pattern with well-developed supragranular layers involved in higher-order associative processing. Functionally, this region participates in reward valuation, decision making under uncertainty, emotional regulation, and integration of sensory, limbic, and autonomic information, contributing to goal-directed behavior and social cognition. Strong connectivity with limbic structures (including the amygdala and ventral striatum), as well as with other prefrontal and cingulate areas, supports its role in evaluating outcomes and modulating behavioral responses. There is no direct Wikipedia article for this composite Talairach label; a closely related structure is the Orbitofrontal cortex.
Brodmann area 11 in the medial frontal gyrus (part of the orbitofrontal/ventromedial prefrontal cortex) has been repeatedly implicated in genetic and GWAS-based studies of cognition, personality, and psychiatric risk, although associations are typically reported at the level of broader prefrontal or orbitofrontal regions rather than this exact Talairach-defined parcel. Large-scale imaging genetics consortia such as ENIGMA and UK Biobank have identified common variants in genes related to synaptic function and neurodevelopment (for example, in or near GRIN2B, BDNF, and MAPT, among others) that modulate frontal cortical thickness, surface area, and gray-matter volume in medial and orbitofrontal regions overlapping BA11. Polygenic risk scores for major depressive disorder, bipolar disorder, schizophrenia, and attention-deficit/hyperactivity disorder show associations with structural and functional alterations in medial orbitofrontal/ventromedial prefrontal cortex, including BA11, consistent with this region’s role in reward valuation and affect regulation. Variants in serotonin and dopamine pathway genes (such as SLC6A4, DRD2, and COMT) have been linked to altered activation of medial orbitofrontal cortex during decision-making and emotional tasks, while GWAS of traits like neuroticism, risk-taking, impulsivity, and subjective well-being report frontal-lobe–enriched genetic effects that often include medial/orbitofrontal territories. Although no single gene has a specific, exclusive link to the bilateral Right Cerebrum.Frontal Lobe.Medial Frontal Gyrus.Gray Matter.Brodmann area 11 label, convergent imaging genetics and psychiatric GWAS findings indicate that this region is a key intermediate phenotype site where distributed polygenic risk influences reward processing, mood regulation, and higher-order social and emotional behavior.
Overview generated by GPT-4o (2026).
Region ID: 236
Hemisphere: bilateral
Atlas: Talairach labels 1mm
Full Quality Version: Download MP4
Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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