The bilateral Right Cerebrum.Frontal Lobe.Middle Frontal Gyrus.Gray Matter.Brodmann area 10 corresponds to a large anterior prefrontal region situated in the rostral portion of the middle frontal gyrus, forming part of the most anterior aspect of the frontal cortex (frontopolar cortex). Brodmann area 10 is implicated in high-order executive functions, including prospective memory, multitasking, abstract reasoning, evaluation of internally generated information, and integration of multiple cognitive operations over extended time scales. It shows extensive connectivity with other prefrontal areas, limbic structures, and association cortices, supporting roles in decision-making, social cognition, and regulation of goal-directed behavior. Functionally, this region is often grouped within the anterior prefrontal or frontopolar cortex and is considered a key hub in large-scale control networks of the human brain. Brodmann area 10
The bilateral right middle frontal gyrus in Brodmann area 10, a key component of anterior prefrontal cortex, has been repeatedly implicated in genetic and genomic studies of higher-order cognition, psychiatric risk, and brain morphology. GWAS of cortical thickness and surface area have identified common variants in genes involved in neurodevelopment and synaptic function—such as those in MAPT, DCC, and various Wnt- and axon-guidance–related loci—associated with structural variation in frontal regions that include BA10. Polygenic risk scores for schizophrenia, bipolar disorder, major depressive disorder, and ADHD show associations with altered gray matter volume and functional activation in this area, consistent with its role in executive control, working memory, and prospective thinking. Imaging–genetics work has linked COMT (e.g., Val158Met), BDNF (Val66Met), and serotonin transporter (SLC6A4) variants to individual differences in activation and connectivity of right middle frontal BA10 during tasks involving cognitive flexibility, reward-based decision-making, and emotion regulation. Autism spectrum disorder and obsessive–compulsive disorder risk genes, particularly those influencing synaptic pruning and excitation–inhibition balance, have also been functionally connected to circuitry encompassing BA10 in transcriptomic and connectome-based association studies. Collectively, these findings suggest that genetic variation affecting neurodevelopmental pathways, dopaminergic and serotonergic signaling, and synaptic plasticity contributes to interindividual differences in structure and function of the right middle frontal BA10, which in turn modulates vulnerability to a range of neuropsychiatric and cognitive phenotypes.
Overview generated by GPT-4o (2026).
Region ID: 411
Hemisphere: bilateral
Atlas: Talairach labels 1mm
Full Quality Version: Download MP4
Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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