The bilateral Right Cerebrum.Frontal Lobe.Rectal Gyrus in the Talairach 1 mm atlas corresponds to the gyrus rectus (straight gyrus), a medial orbital frontal structure lying on the inferior surface of the frontal lobe, adjacent to the olfactory sulcus and overlying the orbital plate of the frontal bone. It is part of the ventromedial prefrontal cortex and is implicated in integrating emotional, reward-related, and autonomic information with higher-order decision-making, as well as aspects of social cognition and value-based behavior. The gyrus rectus has strong connections with limbic and paralimbic regions, including the orbitofrontal cortex, anterior cingulate cortex, and medial temporal structures, and is vascularized primarily by branches of the anterior cerebral artery. No direct Wikipedia article exists under the label “Rectal Gyrus”; the related structure is the Gyrus rectus.
The bilateral right rectus (rectal) gyrus in the frontal lobe, corresponding to orbitofrontal/medial prefrontal cortex in the Talairach 1 mm atlas, is implicated in multiple genetic and GWAS findings primarily through broader orbitofrontal and medial prefrontal measures rather than this subregion alone. Large imaging-genetics consortia (e.g., ENIGMA, UK Biobank) have identified common variants in genes involved in neurodevelopment and synaptic signaling—such as HMGA2, microtubule- and axon-guidance genes, and several intergenic loci—that are associated with cortical thickness, surface area, and volume in orbitofrontal and medial prefrontal regions overlapping the rectus gyrus. Polygenic risk scores for major depressive disorder, bipolar disorder, schizophrenia, and autism spectrum disorder have been linked to structural and functional variation in orbitofrontal/ventromedial prefrontal cortex, with some studies reporting reduced gray matter volume or altered activation in the rectus region in carriers of higher psychiatric genetic risk. GWAS of cognitive traits (general intelligence, educational attainment) and personality dimensions (neuroticism, impulsivity) also show associations with morphology and connectivity in orbitofrontal/medial prefrontal regions, suggesting that genetically influenced variation in this area contributes to affect regulation, decision-making, and social cognition. However, specific locus-level associations uniquely and explicitly attributed to the Talairach-defined “Right Cerebrum.Frontal Lobe.Rectal Gyrus” are limited; most evidence comes from broader orbitofrontal/medial prefrontal ROIs that encompass this gyrus rather than from studies targeting this label alone.
Overview generated by GPT-4o (2026).
Region ID: 144
Hemisphere: bilateral
Atlas: Talairach labels 1mm
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Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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