The bilateral Right Cerebrum.Frontal Lobe.Superior Frontal Gyrus.Gray Matter.Brodmann area 10 corresponds to the most anterior portion of the prefrontal cortex (frontopolar cortex) situated in the superior frontal gyrus of the frontal lobe, occupying the rostral pole of the cerebral hemisphere. This association cortex is heavily interconnected with other prefrontal, limbic, and parietal regions and is implicated in high-level cognitive operations such as prospective memory, multitasking, complex decision-making, abstract reasoning, and the integration of internal goals with external stimuli over extended time scales. It plays a key role in the coordination of simultaneous cognitive processes, the evaluation of alternative courses of action, and the regulation of social and emotional behavior. There is no direct link for this exact composite label; a closely related structure is Brodmann area 10.
The bilateral right superior frontal gyrus (Brodmann area 10) has been repeatedly implicated in genetic studies of higher-order cognition, psychiatric risk, and brain structural variation, although GWAS typically reference imaging-derived phenotypes (e.g., cortical thickness or surface area) rather than the Talairach label explicitly. Large-scale neuroimaging GWAS (e.g., ENIGMA, UK Biobank) have identified common variants in genes involved in neurodevelopment and synaptic function—such as microtubule-associated (MAPT region on 17q21), glutamatergic and GABAergic pathway genes, and genes in Wnt and Notch signaling—associated with frontal lobe cortical thickness or volume, including the superior frontal region encompassing BA10. Polygenic risk scores for schizophrenia, bipolar disorder, major depressive disorder, and ADHD show associations with altered morphology and activation in BA10, and risk loci in CACNA1C, ZNF804A, and other psychiatric GWAS hits have been linked to functional changes in medial and dorsolateral prefrontal territories overlapping this area. BA10-related structural and functional measures also show genetic correlations with traits such as intelligence, educational attainment, working memory performance, and neuroticism, reflecting shared polygenic architecture between frontal association cortex structure and cognitive–affective phenotypes. Although BA10 is less often singled out in isolation, the superior frontal gyrus as part of the prefrontal cortex consistently emerges in multivariate genetic analyses as a key target of distributed polygenic influences on executive control, default mode network function, and vulnerability to mood and psychotic disorders.
Overview generated by GPT-4o (2026).
Region ID: 412
Hemisphere: bilateral
Atlas: Talairach labels 1mm
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Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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