The bilateral Right Cerebrum.Limbic Lobe.Anterior Cingulate corresponds to the anterior portion of the cingulate cortex located on the medial surface of the frontal lobe, forming part of the limbic system and interconnected with prefrontal, motor, and limbic regions. This area is heavily involved in the integration of cognitive and emotional information, playing key roles in attention, error detection, conflict monitoring, motivation, and the regulation of autonomic and affective responses. It contributes to decision-making, reward-based learning, and the modulation of pain and emotional experience through dense connections with the amygdala, prefrontal cortex, and midline thalamic nuclei. Cytoarchitectonically, it includes multiple subregions that support functions ranging from executive control and response selection to the evaluation of emotional salience and internal states. Anterior cingulate cortex
The bilateral right anterior cingulate cortex (ACC) in the limbic lobe, as defined in the Talairach 1 mm atlas, has been repeatedly implicated in genetic studies of psychiatric and neurodevelopmental disorders, cognitive traits, and pain and affective processing. Genome-wide association studies (GWAS) and imaging-genetics analyses link ACC volume, cortical thickness, and functional connectivity to common variants in genes involved in synaptic function, neurodevelopment, and myelination, including loci near or within CACNA1C, MIR137, ZNF804A, DRD2, and GRM3 in schizophrenia and bipolar disorder cohorts; SLC6A4, BDNF, and CRHR1 in depression, anxiety, and stress-related phenotypes; and APOE and other Alzheimer’s disease risk loci in relation to ACC atrophy and hypometabolism. Polygenic risk scores for major depressive disorder, schizophrenia, bipolar disorder, autism spectrum disorder, and attention-deficit/hyperactivity disorder show associations with structural and functional alterations in the ACC, particularly in tasks involving cognitive control, error monitoring, and conflict processing. GWAS of pain sensitivity and chronic pain conditions have identified variants that modulate ACC activation during nociceptive tasks, while large consortia (e.g., ENIGMA, UK Biobank) report heritable variation in ACC morphology and connectivity linked to distributed genetic architectures for intelligence, educational attainment, and personality traits such as neuroticism. Overall, the right anterior cingulate emerges as a key heritable hub where pleiotropic genetic risk factors for multiple psychiatric, cognitive, and pain-related traits converge on structural and functional alterations.
Overview generated by GPT-4o (2026).
Region ID: 373
Hemisphere: bilateral
Atlas: Talairach labels 1mm
Full Quality Version: Download MP4
Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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