The bilateral Right Cerebrum.Limbic Lobe.Anterior Cingulate.Gray Matter.Brodmann area 10 corresponds to the rostral portion of the medial frontal cortex extending into the anterior cingulate region, as defined in the Talairach 1 mm atlas. Brodmann area 10, also known as the frontopolar prefrontal cortex, is a highly developed association area implicated in complex cognitive and affective functions, including prospective memory, multitasking, evaluation of internally generated information, and integration of emotional and autonomic signals with high-level decision-making. Its limbic and anterior cingulate adjacency supports roles in motivation, social cognition, and regulation of attention and behavior, interfacing between emotional processing and executive control networks.
The bilateral Right Cerebrum Limbic Lobe Anterior Cingulate Gray Matter Brodmann area 10 (BA10), a prefrontal region implicated in higher-order cognition and emotional regulation, has been indirectly linked to several genetic associations through imaging genetics and GWAS of brain structure and function. Large-scale GWAS of cortical morphology (e.g., ENIGMA and UK Biobank) have identified multiple loci near genes involved in synaptic development and neurogenesis (such as HMGA2, MEF2C, and PLEKHM1) that influence prefrontal cortical thickness and surface area, which include portions of BA10 and adjacent anterior cingulate cortex. Variants in genes related to monoaminergic signaling and synaptic plasticity—such as COMT, DRD2, 5-HTTLPR (SLC6A4), and BDNF—have repeatedly been associated with functional differences in anterior cingulate and frontopolar activation during cognitive control, emotion regulation, and decision-making tasks, though these findings are often regionally broad and not specific to BA10 alone. Clinically, schizophrenia, major depressive disorder, bipolar disorder, ADHD, and autism spectrum disorder GWAS consistently implicate polygenic architectures that affect fronto-limbic circuits, with PRS (polygenic risk scores) predicting structural and functional alterations in anterior cingulate and rostral prefrontal areas; for example, schizophrenia and depression PRS have been associated with reduced anterior cingulate volume and altered connectivity with BA10-related networks. Additional GWAS of traits such as neuroticism, risk-taking, intelligence, and educational attainment show correlations between associated variants and prefrontal/anterior cingulate measures, suggesting shared genetic influences on both personality/cognitive traits and the integrity of BA10–cingulate circuitry. However, current evidence is largely indirect and distributed across broader prefrontal and cingulate territories, and no single gene or variant is uniquely and specifically established as a determinant of the Talairach-defined BA10 anterior cingulate region.
Overview generated by GPT-4o (2026).
Region ID: 407
Hemisphere: bilateral
Atlas: Talairach labels 1mm
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Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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