The bilateral Right Cerebrum Limbic Lobe Anterior Cingulate White Matter corresponds to the subcortical fiber pathways underlying the anterior cingulate cortex, a key component of the limbic system involved in emotion regulation, motivation, autonomic control, and cognitive processes such as conflict monitoring and decision-making. These white matter tracts consist primarily of myelinated axons that connect the anterior cingulate gyrus with prefrontal, motor, limbic (including amygdala and hippocampus), and thalamic regions, supporting integrated processing of emotional and cognitive information. Functionally, integrity of this white matter is critical for normal affective behavior, pain perception, and executive control, and its disruption has been implicated in neuropsychiatric conditions such as depression, anxiety disorders, obsessive-compulsive disorder, and schizophrenia. There is no direct Wikipedia article for the white matter subdivision alone; a related structure is the overlying Anterior cingulate cortex.
The bilateral right anterior cingulate white matter (Talairach: Right Cerebrum.Limbic Lobe.Anterior Cingulate.White Matter) is implicated in genetic associations primarily via its role in fronto-limbic circuits, myelination, and cingulum bundle integrity rather than region-specific GWAS signals, with most findings coming from imaging–genetics and large-scale neuroimaging consortia (e.g., ENIGMA, UK Biobank). Polygenic risk for major depressive disorder, schizophrenia, bipolar disorder, autism spectrum disorder, and attention-deficit/hyperactivity disorder has been linked to altered anterior cingulate structure and connectivity, including reduced white matter integrity in cingulate pathways. Variants in genes involved in myelination and axonal guidance (e.g., NRG1, ERBB4, MAG, CNTN4, and other adhesion/guidance molecules), as well as glutamatergic and GABAergic signaling genes (e.g., GRIN2A, GAD1), have shown associations with microstructural changes in cingulate-related tracts, often measured by fractional anisotropy or mean diffusivity. GWAS of white matter microstructure and brain connectome measures have identified loci influencing global and tract-specific integrity that include cingulum/anterior cingulate segments, with notable contributions from genes regulating oligodendrocyte function, axonal development, and synaptic plasticity. Additionally, polygenic scores for cognitive performance and educational attainment show correlations with anterior cingulate volume and white matter coherence, reflecting this region’s role in cognitive control and conflict monitoring, while risk alleles for anxiety, neuroticism, and pain sensitivity have been associated with functional and structural alterations in anterior cingulate networks that depend on intact white matter pathways traversing this area.
Overview generated by GPT-4o (2026).
Region ID: 374
Hemisphere: bilateral
Atlas: Talairach labels 1mm
Full Quality Version: Download MP4
Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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