Brodmann area 24 of the cingulate gyrus is a cytoarchitectonically defined region of gray matter within the limbic lobe of the right and left cerebrum, forming part of the anterior cingulate cortex on the medial surface of the frontal lobe. It lies dorsal to the corpus callosum and is characterized by a granular cortical lamination pattern distinct from adjacent Brodmann areas, with dense reciprocal connections to prefrontal, premotor, limbic, and autonomic centers. Functionally, Brodmann area 24 is implicated in emotional processing, motivation, autonomic regulation (including cardiovascular and visceromotor responses), conflict monitoring, and aspects of decision-making and cognitive control, integrating affective and cognitive information to influence behavior. Anterior cingulate cortex
The bilateral right cingulate gyrus gray matter in Brodmann area 24, a core node of the anterior/mid-cingulate limbic network, has been repeatedly implicated in genetic and GWAS-based studies of psychiatric, cognitive, and pain-related traits. Common variants in genes regulating monoaminergic and glutamatergic signaling (notably in serotonin transporter, dopaminergic, and NMDA pathway genes) and synaptic plasticity (including BDNF and related neurotrophin pathways) have been associated with structural volume, cortical thickness, and activation of BA24, particularly in large imaging–genetics consortia (e.g., ENIGMA and UK Biobank). Polygenic risk scores for major depressive disorder, schizophrenia, bipolar disorder, and anxiety disorders show significant correlations with BA24 morphometry and functional connectivity, supporting its role as a convergence zone for psychiatric genetic risk. GWAS of brain structural endophenotypes report heritable variance in cingulate measures, with loci near genes involved in axon guidance, myelination, and calcium-channel function contributing to individual differences. Additional associations link BA24 structure and activity to genetic liability for chronic pain, neuroticism, stress reactivity, and cognitive control, indicating that this region is a genetically sensitive hub for affective regulation, error monitoring, and conflict processing.
Overview generated by GPT-4o (2026).
Region ID: 942
Hemisphere: bilateral
Atlas: Talairach labels 1mm
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Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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