The bilateral Right Cerebrum.Limbic Lobe.Extra-Nuclear.White Matter region in the Talairach 1 mm atlas refers to association and projection white matter tracts coursing through limbic portions of the right cerebral hemisphere outside of the major nuclear gray matter structures (such as the basal ganglia and thalamus). These pathways interconnect key components of the limbic system—including the cingulate gyrus, hippocampal formation, and parahippocampal regions—with cortical and subcortical targets, supporting functions related to emotion, memory, and autonomic regulation. The term “extra-nuclear” emphasizes location in white matter rather than in discrete nuclei, and such tracts may include segments of the cingulum bundle and related limbic association fibers. There is no direct link for this composite Talairach label; a closely related structure is the Limbic system.
Genetic associations specific to the bilateral Right Cerebrum.Limbic Lobe.Extra-Nuclear.White Matter region, as delineated in the Talairach 1 mm atlas, have not been characterized at the fine-grained parcel level, but GWAS and imaging-genetics studies implicate nearby limbic white-matter pathways—especially fronto-limbic and thalamo-limbic tracts—in several heritable traits and disorders. Polygenic influences on limbic white-matter microstructure (e.g., fractional anisotropy and mean diffusivity) have been linked to common variants in genes involved in axonal growth, myelination, and synaptic plasticity, including but not limited to neuregulin/ErbB signaling, MAG, and other oligodendrocyte-related loci. Large-scale ENIGMA and UK Biobank imaging-GWAS have shown that polygenic risk scores for major depressive disorder, schizophrenia, bipolar disorder, and autism spectrum disorder associate with altered limbic white-matter integrity, while Alzheimer’s disease and other neurodegenerative GWAS loci (such as APOE and genes involved in amyloid processing and tau pathways) correlate with atrophy and microstructural changes in adjacent limbic and extra-nuclear white matter. Additional associations have been reported between limbic white-matter metrics and genetic liability to traits such as neuroticism, cognitive performance, and substance use, suggesting that this region participates in broadly heritable networks subserving emotion regulation, memory, and higher-order cognition, even though no single variant has been uniquely tied to the exact Talairach-defined parcel.
Overview generated by GPT-4o (2026).
Region ID: 375
Hemisphere: bilateral
Atlas: Talairach labels 1mm
Full Quality Version: Download MP4
Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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