The bilateral Right Cerebrum.Limbic Lobe.Posterior Cingulate.Gray Matter.Brodmann area 23 corresponds to a portion of the posterior cingulate cortex located within the limbic lobe on the medial surface of the right cerebral hemisphere. Brodmann area 23 is primarily associated with internally directed cognition, including autobiographical memory retrieval, emotional evaluation of self-referential information, and integration of visuospatial and mnemonic inputs. As part of the default mode network, this region shows high metabolic activity at rest and is implicated in consciousness, spatial orientation, and affective processing. Cytoarchitectonically, BA23 is agranular to dysgranular cortex, receiving multimodal inputs from other limbic and association areas, and projecting to structures involved in memory and emotion such as the hippocampal formation and prefrontal cortex. There is no direct Wikipedia article for Brodmann area 23; a closely related structure is the Posterior cingulate cortex.
The bilateral posterior cingulate cortex (PCC; Brodmann area 23 in the limbic lobe) has been repeatedly implicated in imaging genetics and GWAS as a key hub of the default mode network whose gray-matter volume, cortical thickness, functional connectivity, and metabolic activity show significant heritability and specific genetic associations. Large-scale brain MRI GWAS (e.g., ENIGMA, UK Biobank) identify common variants in and near genes involved in neurodevelopment, synaptic function, and myelination—such as CNKSR2, BDNF, MAPT, APOE, and several 17q and 19q loci—as influencing PCC structure or connectivity, particularly its atrophy patterns and amyloid- and tau-related dysfunction in Alzheimer’s disease and mild cognitive impairment. APOE ε4 status is associated with reduced PCC metabolism and early structural changes, while PCC alterations have also been linked to schizophrenia, major depressive disorder, autism spectrum disorder, attention-deficit/hyperactivity disorder, and individual differences in memory, self-referential processing, and general cognitive ability, with polygenic risk scores for these conditions correlating with PCC morphology or connectivity. Additional GWAS focusing on resting-state networks show that genetic variants shaping default mode network connectivity frequently involve PCC-centered networks, implicating pathways of synaptic plasticity, glutamatergic signaling, and lipid metabolism, though many specific SNP–region associations remain below genome-wide significance or have modest effect sizes and require replication.
Overview generated by GPT-4o (2026).
Region ID: 763
Hemisphere: bilateral
Atlas: Talairach labels 1mm
Full Quality Version: Download MP4
Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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