The bilateral Right Cerebrum.Occipital Lobe.Precuneus, as labeled in the Talairach 1 mm Atlas, corresponds to the portion of the precuneus located within or bordering the medial occipital-parietal junction of the right hemisphere, on the medial wall of the cerebral cortex between the cuneus and the posterior cingulate gyrus. Functionally, the precuneus is implicated in visuospatial processing, self-referential thought, aspects of episodic memory retrieval, and integration of sensory information, with this posterior/occipital portion particularly related to visual imagery and higher-order visual processing. It lies within the medial parietal/occipital association cortex and participates in large-scale networks such as the default mode network, contributing to internal mentation and the coordination of visual and cognitive information.
The precuneus, located in the medial parietal/occipital region of the right cerebrum, shows robust heritability in structural and functional MRI GWAS, with multiple genome-wide significant loci influencing its cortical thickness, surface area, and connectivity, including variants near genes involved in neurodevelopment, synaptic function, and lipid metabolism (e.g., MIR2113, DAAM1, HMGA2, and loci in major histocompatibility complex regions). Large-scale imaging-genetics consortia such as ENIGMA and UK Biobank have reported associations between precuneus morphology or resting-state activity and polygenic risk for Alzheimer’s disease, schizophrenia, major depressive disorder, and autism spectrum disorder, consistent with the region’s role in default mode network functioning. GWAS of cognitive traits and educational attainment implicate polygenic influences that partly act through precuneus structure and connectivity, while APOE ε4 and other Alzheimer’s disease risk variants have been linked to altered metabolism, amyloid deposition, and atrophy in medial parietal areas encompassing the precuneus. Additional associations include links between precuneus measures and genetic risk for epilepsy, attention-deficit/hyperactivity disorder, and anxiety-related traits, though these tend to be polygenic and distributed rather than specific to single genes, reflecting the region’s integration in large-scale networks underlying memory, self-referential processing, and visuospatial cognition.
Overview generated by GPT-4o (2026).
Region ID: 828
Hemisphere: bilateral
Atlas: Talairach labels 1mm
Full Quality Version: Download MP4
Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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