The bilateral Right Cerebrum.Parietal Lobe.Paracentral Lobule.Gray Matter.Brodmann area 5 corresponds to a segment of the superior parietal cortex located near the medial aspect of the hemisphere within the paracentral lobule, involved primarily in higher-order somatosensory processing. As part of the posterior parietal cortex, Brodmann area 5 integrates tactile, proprioceptive, and kinesthetic information from the primary somatosensory areas to support complex sensorimotor functions such as limb position sense, movement planning, and coordination in extrapersonal space. Neuronal populations in this region contribute to the internal representation of the body schema and guide voluntary actions by transforming sensory input into motor-relevant signals. There is no direct Wikipedia article for this specific Talairach label; a closely related structure is Brodmann area 5.
The bilateral right paracentral lobule (parietal lobe, gray matter, Brodmann area 5) is part of the medial sensorimotor and somatosensory association cortex, and genetic associations involving this region largely emerge from imaging-genetics and GWAS of cortical morphology and brain-wide networks rather than region-specific candidate-gene work. Large-scale MRI-based GWAS (e.g., ENIGMA, UK Biobank) have linked common variants in genes involved in neurodevelopment, axon guidance, and synaptic plasticity—such as those near MIR137, MAPT, MEF2C, and genes in the Wnt and FGF signaling pathways—to variation in parietal and sensorimotor cortical thickness, surface area, and gyrification, which encompass or include the paracentral lobule. Polygenic risk for schizophrenia, major depressive disorder, autism spectrum disorder, ADHD, and Alzheimer’s disease has been associated with structural and functional alterations in medial parietal and sensorimotor areas, including altered cortical thickness and connectivity in paracentral and adjacent BA5/BA7 territories, suggesting that shared genetic liability to these disorders partially manifests via this region’s morphology and circuitry. GWAS of motor and somatosensory traits—such as handedness, gait and balance phenotypes, and chronic pain—have identified loci (e.g., in genes such as TNC, CNTNAP2, and those regulating corticospinal development) that correlate with volume or activation changes in paracentral/sensorimotor cortex, implicating these regions in the genetic architecture of motor function and pain processing, although most findings are reported at the level of broader sensorimotor or parietal regions rather than BA5 specifically and are not yet finely resolved to the Talairach-defined bilateral right paracentral lobule.
Overview generated by GPT-4o (2026).
Region ID: 1067
Hemisphere: bilateral
Atlas: Talairach labels 1mm
Full Quality Version: Download MP4
Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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