The bilateral Right Cerebrum.Parietal Lobe.Postcentral Gyrus.Gray Matter.Brodmann area 43 corresponds to a small cortical region located in the parietal operculum, bordering the insula and adjacent to primary somatosensory cortex. Traditionally associated with Brodmann area 43, this area is implicated in gustatory processing, integrating taste information with somatosensory input from the oral cavity, tongue, and pharynx. Its gray matter structure participates in sensorimotor and multimodal integration related to feeding and oral behaviors, and may contribute to higher-order perception of flavor and texture. Functionally, BA43 lies within a network involving the insular cortex and secondary somatosensory regions, supporting the convergence of visceral, somatic, and taste signals.
Brodmann area 43 (postcentral gyrus region in the parietal lobe, often linked to primary gustatory and somatosensory processing) has been implicated in genetic studies primarily through its roles in sensory integration, orofacial and gustatory function, and higher-order somatosensory processing rather than via region-specific single-gene associations. Large-scale neuroimaging GWAS, such as those from ENIGMA and UK Biobank, have identified polygenic influences on cortical thickness and surface area in the postcentral and adjacent parietal regions, with common variants in genes involved in neurodevelopment, synaptic function, and axon guidance (for example, loci near HMGA2, IGF1, and genes in Wnt and MAPK pathways) contributing to interindividual variability in somatosensory cortex morphology that encompasses BA43. Genetic risk for neurodevelopmental and psychiatric disorders—including autism spectrum disorder, schizophrenia, and ADHD—has been associated with altered structure and activation of parietal/postcentral regions in imaging–genetics studies, where polygenic risk scores for these conditions correlate with gray-matter changes and functional differences in somatosensory and parietal areas overlapping BA43. In addition, GWAS of traits such as pain sensitivity, tactile perception, handedness, and motor-speech or orofacial traits have reported associations with postcentral and parietal cortical measures that include BA43 territory, though these signals are generally distributed and not specific to this Brodmann area. Overall, current evidence indicates that BA43’s structure and function are influenced by highly polygenic architectures shared with broader somatosensory and parietal networks, rather than by unique, BA43-specific genetic variants.
Overview generated by GPT-4o (2026).
Region ID: 793
Hemisphere: bilateral
Atlas: Talairach labels 1mm
Full Quality Version: Download MP4
Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
This resource is licensed under CC0 1.0 Universal (Public Domain).