The bilateral Right Cerebrum.Parietal Lobe.Supramarginal Gyrus corresponds to the supramarginal gyrus within the inferior parietal lobule of the right cerebral hemisphere, a multimodal association area that wraps around the posterior end of the lateral sulcus. This region integrates somatosensory, auditory, and visual information and is critically involved in phonological processing, language comprehension, articulation planning, and aspects of working memory, as well as in spatial attention, body schema, and social-cognitive functions such as empathy and perspective taking. Lesions in the right supramarginal gyrus have been associated with deficits in spatial awareness, neglect syndromes, and disturbances in praxis and higher-order sensory integration. Supramarginal gyrus
The supramarginal gyrus in the right parietal lobe, as defined in the Talairach 1 mm atlas, has been implicated in multiple genetically influenced traits and disorders through imaging-genetics and GWAS studies of cortical structure and function. Large-scale cortical thickness and surface area GWAS (e.g., ENIGMA and UK Biobank cohorts) have identified common variants near genes involved in neurodevelopment, synaptic organization, and neuronal migration (such as MIR137, SLC39A8, AUTS2, and other loci on chromosomes 3p, 6p, and 17q) that influence interindividual differences in supramarginal gyrus morphology. Polygenic risk for schizophrenia, bipolar disorder, major depression, and autism spectrum disorder shows associations with altered volume or thickness in this region, consistent with its role in language, social cognition, and integration of auditory–somatosensory information. Variants in FOXP2 and related language-network genes have been linked indirectly to functional activation patterns in supramarginal and adjacent inferior parietal regions during speech and phonological tasks. GWAS of reading ability, dyslexia, and educational attainment have identified polygenic effects that partly converge on parietal language and attention networks encompassing the supramarginal gyrus, while ADHD- and cognitive-performance–related loci show correlations with parietal structural metrics. Overall, genetic associations for the bilateral right supramarginal gyrus are largely polygenic and distributed, reflecting shared neurodevelopmental pathways influencing higher-order language, attention, and social-cognitive functions rather than single region-specific genes.
Overview generated by GPT-4o (2026).
Region ID: 883
Hemisphere: bilateral
Atlas: Talairach labels 1mm
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Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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