The bilateral Right Cerebrum.Sub-lobar.Claustrum.Gray Matter corresponds to the claustrum, a thin, irregular sheet of gray matter situated deep within the subcortical region of the cerebral hemisphere, between the insular cortex medially and the putamen of the basal ganglia laterally. It is composed predominantly of densely packed neurons and is extensively interconnected with widespread cortical areas, including frontal, temporal, parietal, and occipital regions, suggesting a role in multisensory integration, coordination of cortical activity, and possibly in consciousness and attention. Functionally, the claustrum is thought to modulate information flow across different cortical networks, though its precise role remains incompletely understood. There is no direct link specifically for “Right Cerebrum.Sub-lobar.Claustrum.Gray Matter,” but it is part of the broader claustrum structure: Claustrum.
The bilateral right claustrum, a sub-lobar gray-matter structure in the Talairach 1 mm atlas, has been implicated indirectly in genetic and GWAS findings through its involvement in large-scale brain networks rather than via claustrum-specific association signals; structural and functional alterations in the claustrum have been reported in neuropsychiatric and neurodevelopmental disorders—such as schizophrenia, major depressive disorder, bipolar disorder, autism spectrum disorder, and epilepsy—in which numerous risk loci (for example in genes related to synaptic signaling, glutamatergic and GABAergic transmission, and neurodevelopmental pathways) have been identified, and imaging–genetics work sometimes links these polygenic risk scores to subcortical and insular–claustral morphology or connectivity. Claustrum volume and connectivity changes have also been observed in substance use disorders and in traits related to consciousness, attention, and sensory integration, though these are typically downstream phenotypes of broader genetic architectures rather than region-specific variants. Large-scale brain-structure GWAS (e.g., ENIGMA and UK Biobank–based studies) that interrogate subcortical and cortical thickness/volume occasionally include the claustrum or adjacent insular/sub-lobar regions, identifying common variants in genes involved in neuronal growth, axon guidance, and cortical development that modulate gray-matter volume or connectivity patterns encompassing the claustrum, but no robust, consistently replicated single-gene or variant association unique to the right claustrum has yet been established.
Overview generated by GPT-4o (2026).
Region ID: 450
Hemisphere: bilateral
Atlas: Talairach labels 1mm
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Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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