The bilateral Right Cerebrum.Sub-lobar.Insula.Gray Matter.Brodmann area 47 corresponds to portions of Brodmann area 47 (also termed the orbital part of the inferior frontal gyrus) that extend into or are closely associated with the anterior insular region in the Talairach 1 mm atlas. Brodmann area 47 is a ventrolateral prefrontal cortex region implicated in higher-order cognitive and affective processes, including semantic processing, language-related functions, reward evaluation, and aspects of social and emotional cognition. Functionally, it is often engaged in integrating sensory, interoceptive, and contextual information with goal-directed behavior, and shows strong connectivity with limbic, temporal, and other prefrontal areas. Although there is no dedicated Wikipedia article for this exact composite label, a closely related and encompassing structure is Brodmann area 47.
The bilateral right insular cortex in Brodmann area 47, as defined in the Talairach 1 mm Atlas, has been implicated in multiple genetic associations primarily through imaging genetics and GWAS of brain structure and function. Large-scale neuroimaging GWAS (e.g., ENIGMA, UK Biobank) have shown that cortical thickness and surface area in the insula and adjacent orbitofrontal/BA47 territory are heritable and associated with common variants in genes involved in neurodevelopment, synaptic function, and cell adhesion, including loci near genes such as FOXP2, DCC, CADM2, and others linked to cortical morphology. Insular and BA47 volume and connectivity patterns have been related to polygenic risk scores for major depressive disorder, schizophrenia, bipolar disorder, and autism spectrum disorder, with several psychiatric GWAS identifying risk variants in genes and pathways (glutamatergic signaling, calcium channel function, synaptic plasticity) that correspond to altered structure or activation in this region. Moreover, GWAS of traits such as negative emotionality, anxiety, risk-taking, impulsivity, and substance use have reported associations with insula/BA47 function or morphology, often mediated by variants in dopaminergic and serotonergic signaling genes and transcriptional regulators active in frontal and insular cortices. Although few studies isolate “right BA47 insula” at the 1 mm Talairach resolution, convergent genetic evidence links the broader right insula–inferior frontal/BA47 complex to affective regulation, interoception, decision-making, and social cognition, with multiple common variants and polygenic architectures contributing to structural and functional variation in this region across psychiatric and behavioral phenotypes.
Overview generated by GPT-4o (2026).
Region ID: 466
Hemisphere: bilateral
Atlas: Talairach labels 1mm
Full Quality Version: Download MP4
Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
This resource is licensed under CC0 1.0 Universal (Public Domain).