The bilateral Right Cerebrum.Sub-lobar.Thalamus.Gray Matter.Lateral Dorsal Nucleus corresponds to the lateral dorsal (LD) nucleus of the thalamus, a higher-order associative thalamic nucleus located in the dorsal tier of the lateral thalamus. It receives convergent inputs from cortical association areas and limbic-related structures, including portions of the hippocampal–parahippocampal region, and projects primarily to the posterior parietal and retrosplenial cortices. Through these connections, the LD nucleus participates in visuospatial processing, navigation, and the integration of sensory and contextual information relevant to memory and attention, acting as a relay that links limbic circuits with multimodal association cortices. There is no direct link for the lateral dorsal nucleus itself; a related entry describing its broader structure is Thalamus.
The lateral dorsal nucleus of the thalamus (bilateral Right Cerebrum.Sub-lobar.Thalamus.Gray Matter.Lateral Dorsal Nucleus in the Talairach 1 mm atlas) is part of the limbic-associated thalamic circuitry, and genetic associations related specifically to this nucleus are generally inferred from broader thalamic or limbic system imaging genetics and GWAS rather than nucleus-specific studies. Large-scale neuroimaging GWAS (e.g., ENIGMA, UK Biobank) have identified multiple common variants influencing thalamic volume and microstructure, including loci near or within genes involved in neurodevelopment, synaptic function, and axonal guidance (such as NTRK1/3, MTOR pathway genes, and several cell-adhesion molecules), though these are typically reported for total thalamus or its major subregions rather than uniquely for the lateral dorsal nucleus. Thalamic structure and connectivity, including limbic and associative nuclei that encompass or neighbor the lateral dorsal nucleus, have been implicated via genetic and imaging studies in schizophrenia, bipolar disorder, major depressive disorder, ADHD, and autism spectrum conditions, often through polygenic risk scores that correlate with thalamic volume or functional connectivity changes. Additionally, variants associated with cognitive traits (general intelligence, memory performance) and neuroticism or anxiety-related personality dimensions have been linked to thalamic morphology, supporting a role for genetically influenced thalamic circuitry in higher-order cognition and affect regulation. However, current GWAS and imaging-genetics literature does not commonly resolve findings at the resolution of the lateral dorsal nucleus specifically, so genetic associations for this region are best understood as part of broader thalamic and limbic network effects.
Overview generated by GPT-4o (2026).
Region ID: 788
Hemisphere: bilateral
Atlas: Talairach labels 1mm
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Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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