The bilateral Right Cerebrum.Temporal Lobe.Middle Temporal Gyrus.Gray Matter.Brodmann area 39 corresponds to the gray matter portion of the angular gyrus region located at the posterior aspect of the middle temporal gyrus within the temporal lobe, as defined in the Talairach 1 mm Atlas. Functionally, this territory lies at the junction of the temporal, parietal, and occipital lobes and is implicated in multimodal integration of visual, auditory, and linguistic information, contributing to language comprehension, reading, semantic processing, and aspects of number cognition and spatial awareness. It receives convergent input from association cortices and participates in distributed networks supporting higher-order cognition, including theory of mind and episodic memory retrieval. There is no direct Wikipedia article for this exact Talairach label; a closely related structure encompassing Brodmann area 39 is the Angular gyrus.
The bilateral right middle temporal gyrus (MTG) in Brodmann area 39—part of the angular/supramarginal–temporal junction in the temporoparietal region—is repeatedly implicated in genetic studies of language, semantic processing, and higher-order social cognition. GWAS of cortical thickness and surface area (e.g., ENIGMA and UK Biobank–based consortia) have linked common variants near genes involved in neurodevelopment and synaptic function—such as MIR2113, DAAM1, and loci in 3p24–p25 and 15q14—to structural variation in temporoparietal and middle temporal regions that include BA39. Polygenic risk for schizophrenia, major depressive disorder, and autism spectrum disorder has been associated with altered gray-matter volume or cortical thickness in the right temporoparietal/MTG area, and risk variants in genes such as DISC1, NRG1, and CNTNAP2 have been related to functional and structural anomalies in this broader territory. Language- and reading-related disorders, including developmental dyslexia and specific language impairment, show associations between variants in FOXP2, KIAA0319, DCDC2, and other phonological/reading gene candidates and atypical activation or morphology in left-dominant but often bilateral temporoparietal–middle temporal cortices encompassing BA39. GWAS of social cognition and theory-of-mind performance, as well as polygenic scores for autism and empathy-related traits, also implicate the right temporoparietal/MTG region, consistent with its role in perspective-taking and semantic–social integration, although precise voxel-level genetic mappings specific to the “Right Cerebrum.Temporal Lobe.Middle Temporal Gyrus.Gray Matter.Brodmann area 39” Talairach label remain largely inferred from broader regional parcellations rather than from this exact atlas-defined volume.
Overview generated by GPT-4o (2026).
Region ID: 704
Hemisphere: bilateral
Atlas: Talairach labels 1mm
Full Quality Version: Download MP4
Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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