The bilateral Right Cerebrum.Temporal Lobe.Transverse Temporal Gyrus.White Matter corresponds to the subcortical myelinated fiber pathways underlying the transverse temporal gyrus (Heschl’s gyrus) in the right temporal lobe, which forms part of the primary auditory cortex. These white matter tracts include short association fibers linking Heschl’s gyrus with adjacent superior temporal regions, as well as longer projection pathways conveying auditory information to and from thalamic and other cortical areas involved in sound processing, speech perception, and auditory scene analysis. This region supports rapid transmission and integration of acoustic signals, contributing to functions such as frequency discrimination, temporal resolution of sounds, and early cortical processing of complex auditory stimuli. There is no direct Wikipedia article for this specific white matter subdivision; a related structure is the Transverse temporal gyrus.
The bilateral Right Cerebrum.Temporal Lobe.Transverse Temporal Gyrus.White Matter, corresponding largely to auditory pathway fibers beneath Heschl’s gyrus, has been implicated in several genetic and GWAS-based findings through its role in auditory processing, language, and temporal-lobe connectivity rather than via region-specific gene discoveries. Variants in genes influencing white-matter microstructure and myelination (for example, ERBB4, NRG1, and other oligodendrocyte-related genes) have shown associations with temporal lobe and auditory-tract integrity in diffusion MRI GWAS, while large-scale imaging-genetics consortia (such as ENIGMA) have linked polygenic scores for schizophrenia, bipolar disorder, and major depression to altered temporal white-matter volumes and fractional anisotropy that include fibers in this region. GWAS of auditory and language-related traits, including speech perception, reading ability/dyslexia, and musical aptitude, have identified loci (e.g., in KIAA0319, DCDC2, FOXP2-regulated networks, and genes affecting cortical thickness and surface area in superior and transverse temporal gyri) that correspond to altered structure or function in auditory cortex and its underlying white matter. Additionally, temporal white-matter changes in this area have been repeatedly reported in genetic neurodevelopmental conditions (such as 22q11.2 deletion syndrome and certain autism spectrum disorder risk gene carriers), as well as in Alzheimer’s disease and epilepsy GWAS endophenotype studies, where risk alleles for these disorders associate with disrupted temporal lobe connectivity encompassing the transverse temporal region.
Overview generated by GPT-4o (2026).
Region ID: 718
Hemisphere: bilateral
Atlas: Talairach labels 1mm
Full Quality Version: Download MP4
Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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