Bilateral Left Cerebrum.Frontal Lobe.Inferior Frontal Gyrus.Gray Matter.Brodmann area 47 corresponds to a ventrolateral prefrontal cortical territory situated in the orbital part of the inferior frontal gyrus, anterior to the insula and adjacent to the orbitofrontal cortex. This association cortex is strongly connected with limbic, temporal, and other prefrontal regions and is implicated in higher-order cognitive and affective processes, including semantic processing, language comprehension, decision-making under uncertainty, reward evaluation, and integration of emotional and contextual information. Neurons in this area contribute to adaptive behavioral responses by linking sensory input and internal states to flexible, goal-directed actions, and show functional specialization related to valuation, inhibition, and complex social cognition. There is no direct Wikipedia article for this exact Talairach label; a closely related structure is Brodmann area 47.
The inferior frontal gyrus (IFG), Brodmann area 47 in the left frontal lobe, has been implicated in multiple genetic and GWAS findings through its roles in language, social cognition, and affective processing. Imaging genetics studies show that common variants in genes related to neurotransmission and synaptic plasticity (e.g., COMT, DRD2, 5-HTTLPR/SLC6A4, BDNF) modulate gray matter volume and functional activation in BA47 during tasks involving semantic processing, emotion regulation, and decision-making. Large-scale GWAS of brain structure (such as ENIGMA and UK Biobank–based analyses) have identified polygenic influences on regional frontal cortical thickness and volume, including IFG/ventrolateral prefrontal territories, with heritability spread across thousands of variants rather than single large-effect loci. Genetic risk for psychiatric disorders—including major depressive disorder, schizophrenia, bipolar disorder, autism spectrum disorder, and social anxiety—has been associated with altered BA47 morphology and activation patterns, often via polygenic risk scores that correlate with reduced gray matter or abnormal reactivity to emotional or social stimuli in this region. Additionally, GWAS of cognitive traits (verbal ability, educational attainment, general intelligence) and personality/behavioral dimensions (risk-taking, neuroticism, impulsivity) report convergent structural and functional associations with the left IFG/BA47, suggesting that the genetic architecture of these traits partly manifests through this language- and emotion-related frontal area, although specific Talairach 2 mm BA47–focused GWAS hits remain diffuse and highly polygenic.
Overview generated by GPT-4o (2026).
Region ID: 185
Hemisphere: bilateral
Atlas: Talairach labels 2mm
Full Quality Version: Download MP4
Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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