Bilateral Left Cerebrum.Frontal Lobe.Medial Frontal Gyrus.Gray Matter.Brodmann area 10 corresponds to the anterior portion of the medial prefrontal cortex, situated in the most rostral part of the frontal lobe (frontopolar cortex). Brodmann area 10 is heavily involved in high-level executive functions, including prospective memory, complex planning, multitasking, and the integration of internal goals with external stimuli. It contributes to social cognition, mentalizing, and evaluation of abstract, future-oriented decisions, often acting as a hub for integrating information from other prefrontal and association cortices. This region shows extensive connectivity with limbic, parietal, and other frontal areas, supporting its role in introspection, decision-making, and regulation of behavior in accordance with long-term goals. There is no direct Wikipedia article for this exact composite label; a related and encompassing structure is Brodmann area 10.
The medial frontal gyrus within Brodmann area 10 (frontopolar cortex) has been implicated in multiple genetic and imaging-genetic associations, although few studies isolate this exact Talairach-defined region. GWAS of cortical thickness and surface area have identified loci in genes such as HMGA2, MIR548F3, and others associated with frontal pole morphology and global frontal lobe measures, suggesting polygenic influences on BA10 structure. Imaging-genetic work in psychiatric disorders shows that risk variants for schizophrenia (e.g., in CACNA1C, ZNF804A), bipolar disorder (e.g., ANK3, CACNA1C), and major depression (e.g., SIRT1, NEGR1, variants in the MHC region) are associated with altered gray matter volume or cortical thickness in medial frontal and frontopolar regions, frequently encompassing BA10. Polygenic risk scores for schizophrenia, bipolar disorder, and ADHD have been linked to cortical thinning and functional alterations in medial prefrontal/BA10 areas in large cohorts such as UK Biobank and ENIGMA, supporting a distributed genetic architecture affecting this region. Variants in genes related to synaptic function and neurodevelopment (e.g., DISC1 pathway genes, BDNF Val66Met) have been associated with altered activation in BA10 during executive function, prospective memory, and social cognition tasks. Additionally, risk alleles for autism spectrum disorder and social behavioral traits show associations with medial prefrontal cortex connectivity and morphology, implicating BA10 in genetically influenced social and higher-order cognitive processes. Overall, genetic influences on BA10 appear highly polygenic and overlapping across cognitive traits and neuropsychiatric disorders, with most evidence coming from broader frontal or medial prefrontal measures rather than this Talairach-specific label alone.
Overview generated by GPT-4o (2026).
Region ID: 406
Hemisphere: bilateral
Atlas: Talairach labels 2mm
Full Quality Version: Download MP4
Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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