The bilateral Left Cerebrum.Frontal Lobe.Medial Frontal Gyrus.Gray Matter.Brodmann area 11 corresponds to a portion of the orbitofrontal cortex located on the medial aspect of the frontal lobe, implicated in higher-order cognitive and affective processes. This region is involved in evaluating reward and punishment, integrating emotional and sensory information for decision-making, and modulating social behavior and personality traits. It participates in adaptive learning, expectation of outcomes, and the regulation of behavioral responses based on changing environmental contingencies, often through connections with limbic structures such as the amygdala and hippocampus. Anatomically, Brodmann area 11 is cytoarchitectonically distinct, characterized by granular frontal cortex features and extensive reciprocal connectivity with other prefrontal and paralimbic regions. There is no direct link for this exact Talairach label; a closely related and encompassing structure is the Orbitofrontal cortex.
The medial frontal gyrus in Brodmann area 11 (BA11), part of orbitomedial prefrontal cortex, has been implicated in numerous genetic and GWAS findings related to higher-order cognition, emotion regulation, and psychiatric vulnerability. Variants in genes affecting synaptic plasticity and monoaminergic signaling—such as COMT (Val158Met), DRD2, and SLC6A4—have been associated with BA11 gray-matter volume and functional activation during decision making, reward processing, and cognitive control. Large-scale GWAS of brain imaging phenotypes (e.g., ENIGMA and UK Biobank) have identified common variants near genes like HMGA2, MAPT, and others that correlate with frontal cortical thickness, surface area, and volume, including medial/orbitofrontal subregions overlapping BA11. Genetic risk scores for major depressive disorder, bipolar disorder, schizophrenia, and ADHD frequently show associations with structural or functional alterations in medial/orbitofrontal areas, with BA11 implicated in altered reward valuation and affective regulation; variants in CACNA1C, ANK3, and GRM3, among others, have been linked to prefrontal abnormalities spanning this region. GWAS of traits such as neuroticism, impulsivity, risk-taking, and cognitive performance also report convergent effects on medial frontal/orbitofrontal morphology and connectivity, suggesting that polygenic influences on personality and decision making partly act through BA11-related circuits, though spatial resolution of most imaging-genetics work limits precise attribution to Talairach-defined BA11.
Overview generated by GPT-4o (2026).
Region ID: 235
Hemisphere: bilateral
Atlas: Talairach labels 2mm
Full Quality Version: Download MP4
Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
This resource is licensed under CC0 1.0 Universal (Public Domain).