The bilateral Left Cerebrum.Frontal Lobe.Middle Frontal Gyrus.Gray Matter.Brodmann area 10 corresponds to the anterior portion of the prefrontal cortex, commonly known as the frontopolar cortex. Brodmann area 10 is among the most evolutionarily expanded regions in humans and is implicated in higher-order cognitive functions including prospective memory, complex planning, multitasking, and the integration of multiple internal goals and external stimuli over extended time scales. It plays a critical role in abstract reasoning, decision making under uncertainty, social cognition, and the evaluation of future consequences, and is heavily interconnected with other prefrontal, limbic, and association cortices. There is no direct link for this exact Talairach-defined region; a closely related structure is Brodmann area 10.
The bilateral left middle frontal gyrus (BA10) has been repeatedly implicated in genetic studies of higher-order cognition, psychiatric risk, and brain structural variation. GWAS of cortical thickness, surface area, and gray matter volume have identified common variants in loci such as CNTNAP2, CAMK2A, KIAA0319, POU3F2, and multiple intergenic regions that influence prefrontal morphology, including BA10. Polygenic scores for general cognitive ability, educational attainment, and working memory often show associations with BA10 structure and activation, consistent with its role in prospective memory, multitasking, and abstract reasoning. Psychiatric GWAS and imaging‑genetics studies link schizophrenia, bipolar disorder, and major depressive disorder risk variants (e.g., in CACNA1C, ZNF804A, GRM3, DRD2, and complement pathway genes like C4) to altered BA10 volume or functional connectivity, and similar patterns occur for anxiety and obsessive–compulsive traits. BA10 measures also show genetic correlations with neurodevelopmental conditions, including ADHD and autism spectrum disorder, reflecting shared polygenic architecture for executive dysfunction. Additionally, loci associated with personality traits (e.g., neuroticism, conscientiousness), risk-taking, and substance use have been connected to BA10 structural and functional differences, highlighting this region as a convergence point where common genetic variation shapes both cortical organization and complex behavior.
Overview generated by GPT-4o (2026).
Region ID: 410
Hemisphere: bilateral
Atlas: Talairach labels 2mm
Full Quality Version: Download MP4
Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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