The bilateral Left Cerebrum.Frontal Lobe.Orbital Gyrus.Gray Matter.Brodmann area 47 corresponds to a portion of the ventrolateral prefrontal cortex situated in the orbitofrontal region, cytoarchitectonically defined by its granular cortical lamination and association with Brodmann area 47. This region participates in higher-order cognitive and affective processes, including semantic language functions, controlled retrieval of verbal information, evaluation of reward and punishment contingencies, and integration of emotional and sensory inputs for decision-making. It is heavily interconnected with limbic structures (such as the amygdala), temporal association cortex, and other prefrontal areas, supporting roles in social cognition, adaptive behavioral regulation, and modulation of affective responses. There is no direct link for this specific composite Talairach label; a closely related structure is Brodmann area 47.
The bilateral left orbitofrontal Brodmann area 47 (inferior frontal/orbital gyrus) is a key node in fronto-limbic and language–semantic networks, and genetic associations typically emerge from imaging-genetics GWAS of cortical thickness, surface area, and gray matter volume, rather than region-specific candidate studies. Large consortia such as ENIGMA and UK Biobank have identified polygenic influences on frontal lobe and orbitofrontal morphology, with variants in genes related to neurodevelopment, synaptic function, and axon guidance (e.g., MIR137, CACNA1C, GRIN2A, and cell-adhesion/axon guidance loci) contributing to structural variation that includes BA47 or its neighboring inferior frontal regions. BA47–adjacent measures are genetically correlated with psychiatric disorders: schizophrenia, major depressive disorder, bipolar disorder, and obsessive–compulsive disorder show GWAS- and polygenic risk score associations with reduced orbitofrontal/inferior frontal gray matter and altered connectivity, partly mediated by shared common variants influencing cortical development and glutamatergic signaling. Furthermore, genetic liability for substance use (alcohol and nicotine), impulsivity, and neuroticism has been linked to structural and functional differences in orbitofrontal/inferior frontal cortex, including BA47, in imaging-genetics studies, indicating that this region is a downstream target of widely distributed polygenic effects rather than a locus with uniquely region-specific variants.
Overview generated by GPT-4o (2026).
Region ID: 146
Hemisphere: bilateral
Atlas: Talairach labels 2mm
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Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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