The bilateral Left Cerebrum.Frontal Lobe.Orbital Gyrus.White Matter refers to the subcortical fiber pathways underlying the orbital gyri of the frontal lobe within the left cerebral hemisphere, as defined in the Talairach 2 mm atlas. This white matter region lies beneath the orbitofrontal cortex and carries cortico-cortical and cortico-subcortical projections involved in integrating sensory, emotional, and reward-related information with executive and decision-making processes. It participates in networks supporting evaluation of stimulus value, affective regulation, and adaptive behavioral control, connecting orbitofrontal cortical areas with limbic structures (such as the amygdala) and other frontal association regions. There is no direct Wikipedia article for this specific white matter label; a related cortical structure is the orbitofrontal cortex: Orbitofrontal cortex.
The bilateral Left Cerebrum Frontal Lobe Orbital Gyrus White Matter (Talairach 2 mm atlas) corresponds largely to fronto-orbital white matter tracts subserving orbitofrontal cortex connectivity, a region repeatedly implicated in imaging genetics and GWAS of brain structure and behavior. Large-scale neuroimaging GWAS (e.g., ENIGMA, UK Biobank) have identified common variants in genes involved in neurodevelopment, axon guidance, and myelination (such as loci near MCPH1, CNTNAP2, PAX6, and general myelin-related pathways) that influence frontal lobe white matter volume, fractional anisotropy, and cortical morphology, with orbitofrontal regions often included in composite frontal measures rather than isolated labels matching the Talairach orbital gyrus WM parcel. Genetic variation affecting frontal white matter has been associated with disorders that frequently show orbitofrontal involvement, including major depressive disorder, bipolar disorder, schizophrenia, obsessive-compulsive disorder, and substance use disorders, where risk loci (e.g., near CACNA1C, GRIN2A, DRD2, and glutamatergic/synaptic genes) correlate with altered fronto-striatal and orbitofrontal connectivity. Polygenic risk scores for these psychiatric conditions and for traits such as impulsivity, neuroticism, and risk-taking behavior have been linked to microstructural changes in orbitofrontal white matter tracts in diffusion MRI studies. However, current genetic findings typically reference broader frontal or orbitofrontal networks rather than the specific bilateral Left Cerebrum.Frontal Lobe.Orbital Gyrus.White Matter label, so associations are inferred from overlapping anatomical definitions rather than from GWAS targeting this exact Talairach parcel.
Overview generated by GPT-4o (2026).
Region ID: 112
Hemisphere: bilateral
Atlas: Talairach labels 2mm
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Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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