The bilateral Left Cerebrum.Frontal Lobe.Precentral Gyrus.White Matter corresponds to the subcortical fiber pathways underlying the left precentral gyrus, the primary motor cortex region responsible for voluntary control of contralateral skeletal musculature. These white matter tracts contain myelinated axons that relay motor commands from cortical pyramidal neurons toward deeper motor pathways, including contributions to the corticospinal tract and other descending motor systems. Functionally, this region supports fine motor control and coordination by transmitting signals essential for the planning, initiation, and execution of goal-directed movements. Although the white matter itself lacks a dedicated Wikipedia page, it is structurally and functionally associated with the Precentral gyrus.
The bilateral Left Cerebrum Frontal Lobe Precentral Gyrus White Matter—corresponding largely to primary motor cortex output pathways—has been implicated in genetic imaging and GWAS studies through its role in motor function, cortical thickness, and white matter microstructure (e.g., fractional anisotropy and mean diffusivity). Large-scale neuroimaging GWAS, such as those using UK Biobank and ENIGMA cohorts, have identified polygenic influences on precentral gyrus morphology and white matter integrity, with notable contributions from genes involved in axonal guidance, synaptic function, and myelination (including loci near genes such as FOXP2, CNTNAP2, DISC1, and multiple oligodendrocyte-related genes). Variants influencing this region’s structure or connectivity have been associated with motor-related disorders (e.g., Parkinson’s disease, amyotrophic lateral sclerosis, and dystonia), neurodevelopmental conditions with motor and coordination deficits (e.g., ADHD and autism spectrum disorder), and complex traits such as general cognitive function and educational attainment through shared genetic architecture affecting frontal networks. Imaging-genetic studies of white matter tracts emerging from the precentral gyrus (including corticospinal and fronto-striatal pathways) further link common variants to susceptibility for stroke-related motor outcome, multiple sclerosis lesion burden, and cerebral small vessel disease, indicating that this region’s white matter characteristics are shaped by a broad polygenic background that overlaps with risk architecture for both neurodegenerative and neurovascular phenotypes.
Overview generated by GPT-4o (2026).
Region ID: 685
Hemisphere: bilateral
Atlas: Talairach labels 2mm
Full Quality Version: Download MP4
Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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