The bilateral Left Cerebrum.Frontal Lobe.Superior Frontal Gyrus.White Matter corresponds to the subcortical fiber tracts underlying the superior frontal gyrus in the frontal lobe of the left hemisphere. This white matter region contains association fibers interconnecting medial and lateral frontal cortical areas, including premotor and prefrontal regions, and contributes to long-range frontal networks involved in higher-order executive functions, attention, working memory, and motor planning. It also participates in intrahemispheric communication with adjacent frontal gyri and receives projections from and sends projections to subcortical structures via larger frontal white matter bundles. There is no direct Wikipedia article for this specific white matter subdivision; see the related cortical region: Superior frontal gyrus.
The bilateral Left Cerebrum.Frontal Lobe.Superior Frontal Gyrus.White Matter, as defined in the Talairach 2 mm atlas, participates in executive control, working memory, and self-referential processing, and genetic associations involving this region largely come from imaging genetics and GWAS of structural and functional measures. Variants in genes related to myelination and axonal integrity (e.g., MAG, MBP, PLP1, and other oligodendrocyte- and microglia-related loci) have been associated with white matter microstructure in frontal regions, including superior frontal pathways, often indexed by diffusion MRI measures such as fractional anisotropy. Large GWAS of cortical morphology (ENIGMA and UK Biobank) have identified multiple loci (e.g., in or near genes like CENPW, IGF1, TCF4, and variants in the major histocompatibility complex region) that influence frontal cortical thickness and surface area, which partially extend into superior frontal territory and are coupled with underlying white matter. Genetically mediated alterations in this region’s white matter have been implicated in risk for schizophrenia, bipolar disorder, major depressive disorder, and attention-deficit/hyperactivity disorder, where polygenic risk scores correlate with disrupted frontal white matter tracts and connectivity. GWAS of cognitive traits (general intelligence, educational attainment, and executive function) also show overlap between associated loci and genes affecting frontal lobe structure and connectivity, suggesting that heritable variation in the superior frontal gyrus white matter contributes to interindividual differences in higher-order cognition and vulnerability to neuropsychiatric disorders, though specific, region-exclusive genetic associations for this precise Talairach label remain relatively nonspecific and distributed across polygenic architectures.
Overview generated by GPT-4o (2026).
Region ID: 155
Hemisphere: bilateral
Atlas: Talairach labels 2mm
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Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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