Bilateral Left Cerebrum Limbic Lobe Anterior Cingulate Gray Matter Brodmann area 32 corresponds to a medial frontal cortical region within the anterior cingulate gyrus, classified cytoarchitectonically as BA32 in the Talairach 2 mm atlas. This area forms part of the limbic lobe and is involved in integrating emotional, autonomic, and cognitive information, contributing to functions such as conflict monitoring, motivational drive, and regulation of affective responses. Anatomically, BA32 lies dorsal to the genu of the corpus callosum and adjacent to other cingulate and medial prefrontal areas, with dense connectivity to prefrontal, limbic, and subcortical structures including the amygdala and thalamus. There is no direct Wikipedia article specifically for Brodmann area 32; a closely related structure is the Anterior cingulate cortex.
Genetic associations involving the anterior cingulate cortex (ACC), including Brodmann area 32 in the bilateral left limbic lobe, have emerged primarily from neuroimaging genetics and GWAS of brain structure and function, implicating loci that influence cortical thickness, surface area, and connectivity of cingulate regions. Large-scale GWAS of MRI-derived brain phenotypes (e.g., ENIGMA and UK Biobank studies) have identified variants near genes such as HMGA2, TESC, KIAA0586, and others as associated with cingulate cortical measures, while polygenic scores for schizophrenia, major depressive disorder, bipolar disorder, ADHD, and anxiety traits show correlations with ACC morphology and activation patterns. ACC/BA32 has been repeatedly implicated in genetic studies of emotion regulation, cognitive control, pain sensitivity, and risk-related decision making, with dopaminergic (COMT), serotoninergic (5-HTTLPR/SLC6A4), and glutamatergic (GRM, GRIN gene families) variants commonly influencing ACC function and associated endophenotypes. GWAS of psychiatric disorders such as schizophrenia, depression, and PTSD, and traits like neuroticism and risk-taking, often show convergent evidence: risk alleles are linked to altered ACC structure or functional connectivity, suggesting that genetic variation shaping ACC/BA32 contributes to vulnerability for mood and psychotic disorders, as well as individual differences in executive control and affective processing.
Overview generated by GPT-4o (2026).
Region ID: 395
Hemisphere: bilateral
Atlas: Talairach labels 2mm
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Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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