The bilateral Left Cerebrum.Limbic Lobe.Anterior Cingulate.White Matter corresponds to the deep myelinated fiber pathways underlying the anterior cingulate cortex, a key region of the limbic lobe situated on the medial surface of the frontal lobe. These white matter tracts interconnect the anterior cingulate with prefrontal, premotor, limbic, and subcortical structures, supporting functions such as emotion regulation, motivation, autonomic control, and aspects of cognitive control and conflict monitoring. As part of larger bundles (including cingulum fibers), this region contributes to integration of affective and cognitive information and facilitates communication between the medial frontal cortex and other limbic and association areas. There is no direct link for this specific white matter label; see the related cortical region: Anterior cingulate cortex.
The bilateral Left Cerebrum Limbic Lobe Anterior Cingulate white matter (Talairach 2 mm atlas) lies within fronto-limbic circuitry that has been repeatedly implicated in genetic and GWAS studies of psychiatric, cognitive, and pain-related traits, although most work examines gray matter or functional measures rather than this specific white-matter label. Polygenic risk scores and GWAS for major depressive disorder, bipolar disorder, schizophrenia, and anxiety consistently implicate genes involved in synaptic signaling, glutamatergic transmission, and myelination (e.g., CACNA1C, GRIN2A, NRG1, OLIG2), with downstream structural and connectivity effects in anterior cingulate networks. Imaging genetics studies link risk variants in serotonin-related (5-HTTLPR/SLC6A4), dopamine-related (COMT), and BDNF (Val66Met) pathways to altered anterior cingulate microstructure (e.g., fractional anisotropy in cingulum bundle white matter) and functional responses during emotion regulation, conflict monitoring, and pain processing. Large ENIGMA and UK Biobank GWAS of white-matter integrity identify loci affecting oligodendrocyte function and axonal development (such as genes near MAG, MBP, and CNTN4) that modulate cingulate and cingulum tract diffusion metrics, which in turn associate genetically with depression, neuroticism, ADHD, and cognitive performance. Additionally, variants influencing inflammatory and immune pathways (e.g., MHC region on chromosome 6) show pleiotropic effects on fronto-limbic connectivity, including anterior cingulate white matter, in studies of schizophrenia and autoimmune-related mood symptoms. Overall, genetic findings converge on pathways governing myelination, synaptic plasticity, and neuromodulator signaling that shape anterior cingulate white-matter organization and confer susceptibility to mood and psychotic disorders, pain sensitivity, and individual differences in cognitive control and emotional reactivity.
Overview generated by GPT-4o (2026).
Region ID: 371
Hemisphere: bilateral
Atlas: Talairach labels 2mm
Full Quality Version: Download MP4
Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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