Bilateral Left Cerebrum.Limbic Lobe.Cingulate Gyrus.Gray Matter.Brodmann area 32 corresponds to a medial prefrontal sector of the anterior cingulate cortex, situated in the limbic lobe along the cingulate gyrus, with gray matter cytoarchitecture characteristic of agranular cortex. Brodmann area 32 is implicated in high-level integrative functions, including emotional regulation, motivational processing, decision-making under conflict, and aspects of autonomic control, through extensive connections with the prefrontal cortex, limbic structures (such as the amygdala), and subcortical nuclei. Its bilateral representation enables coordinated modulation of affective and cognitive processes, contributing to adaptive behavioral responses and internal state monitoring. There is no direct link for Brodmann area 32; see the related structure Anterior cingulate cortex.
Brodmann area 32 (dorsal anterior cingulate / pregenual cingulate within the limbic lobe) has been repeatedly implicated in genetic studies of psychiatric, cognitive, and pain-related phenotypes, although most associations derive from regional or network-level imaging genetics rather than BA32-specific Talairach labels. GWAS and imaging–genetics studies link variation in BA32 structure and function to polygenic risk for major depressive disorder, schizophrenia, bipolar disorder, anxiety disorders, and attention-deficit/hyperactivity disorder, often through common variants in genes affecting glutamatergic and monoaminergic signaling (e.g., CACNA1C, GRM3, DRD2, SLC6A4), synaptic plasticity, and neurodevelopment. BA32 gray matter volume and activity show heritable variation and have been associated with genetic risk scores for depression and neuroticism, as well as with cognitive control and executive-function traits; several large consortia (e.g., ENIGMA) have reported that cingulate morphology is influenced by genome-wide polygenic architecture overlapping with psychiatric disorders. Additionally, functional and structural characteristics of this region have been linked to genetic variants affecting pain sensitivity, emotion regulation, and stress reactivity (including HPA-axis–related genes), and BA32 activation patterns are frequently used as intermediate phenotypes in imaging GWAS of mood and anxiety traits. Overall, genetic influences on BA32 are best described as part of broader cingulate and fronto-limbic circuits involved in cognitive control, affective regulation, and psychopathology, rather than as highly specific single-gene associations with this Talairach-defined region.
Overview generated by GPT-4o (2026).
Region ID: 945
Hemisphere: bilateral
Atlas: Talairach labels 2mm
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Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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