The bilateral Left Cerebrum.Occipital Lobe.Inferior Occipital Gyrus.White Matter refers to the subcortical fiber tracts underlying the inferior occipital gyrus in the left cerebral hemisphere, as defined in the Talairach 2 mm atlas. This white matter region contains association fibers linking occipital visual cortices with temporal and parietal regions, contributing to the transmission and integration of visual information, particularly along ventral visual pathways involved in object recognition. It includes components of long-range tracts such as the inferior longitudinal fasciculus and other occipito-temporal connections, and is vascularized mainly by branches of the posterior cerebral artery. Functionally, lesions in this area may disrupt visual processing and higher-order visual perception without necessarily damaging the overlying cortical gray matter. There is no direct Wikipedia article for this specific white matter region; a closely related cortical structure is the Occipital lobe.
The bilateral left inferior occipital gyrus white matter (Talairach 2 mm atlas) lies within the ventral visual stream and has been implicated by imaging–genetics and GWAS-derived polygenic score studies in visual processing, face recognition, and reading-related circuitry, though few findings target its white matter specifically at fine-grained atlas resolution. Large neuroimaging GWAS (e.g., UK Biobank–based) have identified common variants in genes involved in axonal guidance and myelination—such as CNTN4, ROBO1, NRXN1, and MAG—that influence occipital lobe white matter microstructure (FA, MD, and other diffusion measures), with some loci overlapping genetic risk for neurodevelopmental and psychiatric conditions including autism spectrum disorder, schizophrenia, and dyslexia. Polygenic risk scores for major depression, schizophrenia, bipolar disorder, and ADHD show associations with altered occipital white matter integrity and volume, suggesting shared genetic architecture between these disorders and occipital connectivity. Rare variants and CNVs affecting synaptic and neurodevelopmental genes (e.g., 22q11.2, 16p11.2) have also been linked to atypical occipital white matter and visual processing deficits. Additionally, GWAS of brain structure and connectivity indicate that occipital white matter is influenced by variants in general neurodevelopmental pathways (Wnt signaling, axon guidance, synaptic formation), although these associations are generally reported at the level of occipital lobe or visual tract measures rather than the specific inferior occipital gyrus white matter label.
Overview generated by GPT-4o (2026).
Region ID: 255
Hemisphere: bilateral
Atlas: Talairach labels 2mm
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Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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