The bilateral Left Cerebrum.Parietal Lobe.Angular Gyrus.Gray Matter.Brodmann area 39 corresponds to a heteromodal association cortical region located in the inferior parietal lobule, surrounding the posterior end of the superior temporal sulcus. Brodmann area 39 (angular gyrus) integrates visual, auditory, and somatosensory information and is critically involved in language-related processes (reading, writing, semantic processing), number comprehension, spatial cognition, theory of mind, and aspects of episodic memory retrieval. It participates in the default mode and fronto-parietal networks, receiving multimodal input from temporal and occipital cortices and projecting to prefrontal association areas, thus supporting higher-order symbolic and conceptual functions. Angular gyrus
The bilateral left angular gyrus (parietal lobe, Brodmann area 39) has been implicated in multiple genetic and GWAS-based associations primarily through imaging genetics and large-scale neuroimaging consortia. Variants in genes related to synaptic plasticity and neurodevelopment (such as BDNF, COMT, and DISC1) have been reported to influence gray matter volume, cortical thickness, or functional activation in this region, particularly in the context of language, reading, and higher-order cognitive functions. GWAS of brain morphology (e.g., ENIGMA studies) have identified loci that modulate parietal and temporoparietal cortical measures that include the angular gyrus, with some overlapping risk variants for schizophrenia, major depressive disorder, and bipolar disorder influencing connectivity and structure within BA39 as part of broader fronto-parietal and default mode networks. Genetic studies of developmental dyslexia and other language-related disorders have occasionally highlighted angular gyrus involvement, although associations typically map to networks rather than a single region, with risk loci in genes such as DCDC2 and KIAA0319 affecting temporo-parietal systems that encompass BA39. Additionally, GWAS of educational attainment, general cognitive ability, and mathematical skills have linked polygenic scores to structural and functional variation in the angular gyrus, reflecting its role in semantic processing, number cognition, and multimodal integration, though these associations are generally diffuse and mediated via widespread cortico-cortical networks rather than region-specific genetic effects.
Overview generated by GPT-4o (2026).
Region ID: 967
Hemisphere: bilateral
Atlas: Talairach labels 2mm
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Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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