Bilateral Left Cerebrum.Parietal Lobe.Superior Parietal Lobule.Gray Matter.Brodmann area 5 is a somatosensory association region located in the superior parietal lobule of the left hemisphere, involved in higher-order processing and integration of tactile, proprioceptive, and kinesthetic information. It contributes to the construction of internal representations of the body and external space, supporting functions such as sensorimotor coordination, body schema, and aspects of spatial attention and visually guided actions. Neuronal populations in this area receive convergent inputs from primary somatosensory cortex and other association areas, enabling complex transformations of sensory signals into motor-relevant formats and contributing to the perception of object size, shape, and limb position. There is no direct Wikipedia article for “Brodmann area 5”; a closely related structure is the Superior parietal lobule.
The bilateral superior parietal lobule (Brodmann area 5) has emerged in genetic and imaging-genetics studies as a key hub for visuospatial integration, attention, and sensorimotor processing, with several genetic associations indirectly implicating this region. Large GWAS of cortical thickness and surface area (e.g., ENIGMA and UK Biobank) have identified variants in neurodevelopmental and synaptic genes—such as those near MAPT, KIAA0586, and genes in Wnt and axon-guidance pathways—associated with structural measures in parietal cortex, including superior parietal regions. Polygenic risk scores for schizophrenia, ADHD, and autism spectrum disorder have been linked to altered superior parietal lobule volume or connectivity in imaging-genetics work, suggesting that common psychiatric risk alleles influence its development and function. Variants in genes related to Alzheimer’s disease risk (e.g., APOE ε4 and loci such as BIN1 and CLU) have been associated with parietal atrophy and disrupted parietal networks, including BA5, in neurodegeneration studies, while GWAS of general cognitive ability and educational attainment show overlapping genetic architectures with parietal morphometry and activation in tasks engaging the superior parietal lobule. Additionally, GWAS of motor coordination and gait, as well as chronic pain and somatosensory traits, have highlighted genes affecting parietal and sensorimotor circuitry, indirectly implicating BA5’s somatosensory integration role, although specific single-gene associations uniquely and exclusively tied to Brodmann area 5 remain limited and typically emerge as part of broader parietal or multimodal association cortex findings.
Overview generated by GPT-4o (2026).
Region ID: 1097
Hemisphere: bilateral
Atlas: Talairach labels 2mm
Full Quality Version: Download MP4
Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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