The bilateral left cerebrum parietal lobe, superior parietal lobule white matter refers to the subcortical association fiber tracts underlying the superior parietal lobule in the left hemisphere, connecting this region with other parietal, frontal, and occipital areas. The superior parietal lobule is involved in higher-order somatosensory processing, visuospatial integration, body representation, and attention, and its white matter supports communication within these functional networks, including dorsal visual and sensorimotor pathways. Damage to this white matter can contribute to deficits in spatial orientation, tactile perception, and coordinated visually guided actions. There is no direct link for this specific white matter subdivision; a closely related cortical region is the Superior parietal lobule.
The bilateral Left Cerebrum Parietal Lobe Superior Parietal Lobule White Matter, as defined in the Talairach 2 mm atlas, is implicated by genetic and imaging-genetics studies in networks supporting visuospatial attention, sensorimotor integration, and high-level cognition. Large GWAS of brain structure (e.g., ENIGMA and UK Biobank cohorts) have identified common variants in and near genes such as HMGA2, KTN1, DLG2, and IGF1 that influence parietal lobe surface area, cortical thickness, and underlying white-matter microstructure (e.g., fractional anisotropy) in superior parietal regions. Polygenic risk for schizophrenia, bipolar disorder, and major depressive disorder has been associated with altered superior parietal lobule connectivity and white-matter integrity, while autism spectrum disorder risk variants and genes involved in synaptic development (e.g., CNTNAP2, SHANK3) show links to atypical parietal networks supporting social cognition and sensory integration. ADHD and educational attainment GWAS have connected alleles in neurodevelopmental and axon guidance genes (such as DRD2, SEMA3A, and CNTN4) to structural and functional variation in parietal white matter critical for attention and working memory. Furthermore, risk loci for Alzheimer’s disease and other dementias (including APOE and CLU) have been associated with early changes in parietal white-matter tracts, consistent with the superior parietal lobule’s involvement in visuospatial and attentional deficits. Overall, genetic influences on neurodevelopment, myelination, synaptic plasticity, and neurodegeneration converge on the superior parietal lobule’s white matter, linking this region to a spectrum of cognitive traits and neuropsychiatric and neurodegenerative disorders.
Overview generated by GPT-4o (2026).
Region ID: 1041
Hemisphere: bilateral
Atlas: Talairach labels 2mm
Full Quality Version: Download MP4
Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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