The bilateral Left Cerebrum.Sub-lobar.Thalamus.Gray Matter.Lateral Posterior Nucleus corresponds to the lateral posterior nucleus of the thalamus, a higher-order relay and association nucleus located in the posterior portion of the thalamus within the sub-lobar gray matter of the cerebral hemispheres. This nucleus is involved in multimodal sensory integration and is closely related to the pulvinar and other posterior thalamic nuclei, contributing to attentional processes, visuospatial functions, and cortico-cortical communication between parietal, temporal, and occipital association areas. Through reciprocal connections with these cortical regions, the lateral posterior nucleus participates in the modulation of perceptual processing and the coordination of complex cognitive tasks that require integration of sensory information. There is no direct link for the lateral posterior nucleus; a related structure is the Thalamus.
Genetic associations involving the Left thalamus, particularly sub-lobar gray matter including the lateral posterior nucleus as defined in the Talairach 2 mm Atlas, are largely inferred from imaging genetics and GWAS of thalamic volume and connectivity rather than nucleus-specific studies. Large-scale GWAS (e.g., ENIGMA and UK Biobank–based analyses) have identified multiple loci influencing thalamic structure, including variants in and near genes such as HMGA2, KCNK2, DLG2, and COL4A2, which are implicated in neurodevelopment, synaptic function, and vascular integrity. Polygenic risk for schizophrenia, bipolar disorder, major depression, and autism spectrum disorder has been associated with alterations in thalamic volume and thalamo-cortical connectivity, suggesting that common risk alleles exert part of their effect through this region’s circuitry. Thalamic nuclei, including posterior relay and association nuclei, show expression and regulatory effects of genes linked to cognition, attention, and sensory integration, consistent with findings that genetic variants associated with intelligence, educational attainment, and sleep traits are related to thalamic morphology and function in imaging genetics studies. However, current GWAS generally treat the thalamus as a whole or subdivide it into broad nuclei groups, so direct, nucleus-specific genetic associations for the lateral posterior nucleus remain limited and are usually inferred from broader thalamic or posterior association-thalamic analyses rather than targeted genetic studies of this precise Talairach-defined region.
Overview generated by GPT-4o (2026).
Region ID: 725
Hemisphere: bilateral
Atlas: Talairach labels 2mm
Full Quality Version: Download MP4
Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
This resource is licensed under CC0 1.0 Universal (Public Domain).