The bilateral Right Cerebrum.Frontal Lobe.Medial Frontal Gyrus.Gray Matter.Brodmann area 32 corresponds to the dorsal portion of the anterior cingulate cortex (ACC), a medial frontal region implicated in cognitive control, conflict monitoring, decision-making, and the regulation of emotional and autonomic responses. This agranular cortical area integrates inputs from prefrontal, limbic, and motor systems, playing a central role in evaluating actions and outcomes, adjusting behavior, and linking motivational and affective states to goal-directed activity. Functionally, BA32 contributes to error detection, performance monitoring, and the modulation of attention, and is involved in neuropsychiatric conditions such as depression, anxiety, and obsessive-compulsive disorder. There is no direct link for “Brodmann area 32,” but a closely related structure is the Anterior cingulate cortex.
The bilateral Right Cerebrum.Frontal Lobe.Medial Frontal Gyrus.Gray Matter.Brodmann area 32 (dorsal/rostral anterior cingulate–medial prefrontal region) has been repeatedly implicated in genetic studies of psychiatric and cognitive traits, mainly through imaging genetics and GWAS of brain structure and function. Large-scale neuroimaging GWAS (e.g., ENIGMA, UK Biobank) have identified common variants near genes involved in synaptic plasticity, neurodevelopment, and glutamatergic signaling (such as CACNA1C, GRIN2B, and genes in the major histocompatibility complex region) that are associated with cortical thickness, surface area, and activation patterns in medial frontal and anterior cingulate territories overlapping BA32. Polygenic risk scores for major depressive disorder, schizophrenia, bipolar disorder, and ADHD are consistently associated with altered gray matter volume or functional connectivity in this region, which is central to cognitive control, error monitoring, and emotion regulation. Disorder-specific GWAS have further linked BA32-related structural or activation differences to variants in genes such as SLC6A4 (serotonin transporter), BDNF, and COMT, reflecting serotonergic and dopaminergic modulation of medial prefrontal circuitry. In anxiety disorders, PTSD, and obsessive-compulsive disorder, genetic risk variants influencing fronto-limbic connectivity often show correlates in BA32, while personality and temperament GWAS (e.g., neuroticism, harm avoidance) have pointed to overlapping medial frontal/anterior cingulate loci. Although the Talairach 2 mm atlas label is anatomical rather than genetic, convergent evidence indicates that BA32 lies within a genetically sensitive hub where numerous common variants exert small but detectable effects on morphology, activation, and connectivity underlying vulnerability to mood, psychotic, and anxiety disorders as well as individual differences in executive and affective traits.
Overview generated by GPT-4o (2026).
Region ID: 612
Hemisphere: bilateral
Atlas: Talairach labels 2mm
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Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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