The bilateral Right Cerebrum.Frontal Lobe.Medial Frontal Gyrus.Gray Matter.Brodmann area 6 corresponds primarily to premotor and supplementary motor cortical regions situated anterior to the precentral gyrus on the medial aspect of the frontal lobe. This agranular cortex is critically involved in the planning, sequencing, and initiation of voluntary movements, integration of proprioceptive and sensory information for motor preparation, and coordination of complex, learned motor behaviors, including bimanual actions and internally generated movement patterns. Activity in this region is associated with motor imagery, timing of actions, and aspects of executive control over motor output, and it forms part of frontal motor networks interconnected with primary motor cortex, basal ganglia, thalamus, and cerebellum. There is no direct link for this exact Talairach label; a closely related structure is Premotor cortex.
The bilateral right medial frontal gyrus (Brodmann area 6, premotor/supplementary motor region) has been implicated in multiple genetic and GWAS findings, largely through imaging-genetics studies that link common variants to regional gray matter volume, cortical thickness, and functional activation. Variants in genes related to synaptic function and neurodevelopment—such as COMT, BDNF (e.g., Val66Met), DISC1, and CACNA1C—have repeatedly shown associations with structural and functional measures in medial frontal and adjacent premotor areas, often in the context of schizophrenia, bipolar disorder, and major depression. Large-scale imaging GWAS consortia (e.g., ENIGMA, UK Biobank–based studies) have identified polygenic influences on frontal cortical morphometry, including BA6, with risk alleles for psychiatric disorders and neurodevelopmental conditions (schizophrenia, ADHD, autism spectrum disorder) showing distributed effects that encompass medial frontal regions involved in motor planning, cognitive control, and default-mode/salience network interactions. Medial frontal BA6 has also been linked in genetic studies to traits such as impulsivity, cognitive flexibility, and response inhibition, as well as to motor and tic disorders (including Tourette syndrome) via genes affecting cortico-striato-thalamo-cortical circuitry. Although findings are typically not specific to the Talairach “Right Cerebrum.Frontal Lobe.Medial Frontal Gyrus.Gray Matter.Brodmann area 6” label at 2 mm resolution, convergent genetic evidence supports a role for this region as a key node through which polygenic risk for psychiatric, motor, and cognitive traits exerts structural and functional brain effects.
Overview generated by GPT-4o (2026).
Region ID: 1011
Hemisphere: bilateral
Atlas: Talairach labels 2mm
Full Quality Version: Download MP4
Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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