The bilateral Right Cerebrum.Frontal Lobe.Middle Frontal Gyrus.Gray Matter.Brodmann area 10 corresponds to the anterior portion of the prefrontal cortex located in the frontal lobe, occupying the most rostral part of the middle frontal gyrus. Brodmann area 10, often referred to as the frontopolar prefrontal cortex, is implicated in high-level executive functions, including prospective memory, complex reasoning, multitasking, and integration of internal goals with external stimuli. It plays a critical role in planning, decision-making, social cognition, and the evaluation of long-term outcomes, contributing to the regulation of behavior in accordance with abstract rules and future intentions. Cytoarchitectonically, this region is characterized by a highly granular cortex with distinct laminar organization, and it maintains widespread reciprocal connections with other prefrontal, parietal, limbic, and temporal areas, supporting its integrative cognitive functions. There is no dedicated Wikipedia page for this exact Talairach label; a closely related structure is Brodmann area 10.
The bilateral right middle frontal gyrus (BA10) gray matter has been implicated in numerous genetic and GWAS findings, largely through imaging genetics studies linking common variants to prefrontal structure and function. Variants in COMT (notably Val158Met), DRD2/ANKK1, and genes involved in dopaminergic signaling have been associated with BA10 volume and activation during executive function, working memory, and decision‑making tasks. Large-scale GWAS of cortical thickness and surface area have identified loci near genes such as CENPW, MIR4697, TBR1, and PAX6 that influence frontal pole and adjacent middle frontal morphology, with BA10 often encompassed in these frontal measurements. Genetic studies of schizophrenia, bipolar disorder, major depressive disorder, ADHD, and autism spectrum disorder consistently implicate BA10 through reduced or altered gray matter volume and connectivity, with polygenic risk scores for these conditions correlating with structural and functional variation in this region. BA10 has also been linked to risk variants for cognitive traits (general intelligence, educational attainment) and personality dimensions (e.g., neuroticism), where higher polygenic scores often track with differences in prefrontal gray matter and activation patterns. Additionally, GWAS of substance use, impulsivity, and risk‑taking behavior have associated frontal pole/middle frontal GWA loci and polygenic risk with BA10 functional differences, reinforcing this region’s role as a convergence point for genetic influences on higher-order cognition, affect regulation, and psychiatric vulnerability.
Overview generated by GPT-4o (2026).
Region ID: 411
Hemisphere: bilateral
Atlas: Talairach labels 2mm
Full Quality Version: Download MP4
Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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