The bilateral Right Cerebrum.Frontal Lobe.Middle Frontal Gyrus.Gray Matter.Brodmann area 6 corresponds to a portion of the premotor cortex and supplementary motor area located anterior to the primary motor cortex in the frontal lobe. This region plays a central role in the planning, sequencing, and preparation of voluntary movements, integrating sensory inputs and higher-order cognitive signals to organize motor programs before execution. It contributes to motor learning, coordination of complex and bimanual actions, and aspects of eye and limb movement control, with strong connectivity to primary motor, parietal, and basal ganglia circuits. Brodmann area 6 is also implicated in motor imagery and movement anticipation, reflecting its function in transforming intentions into organized motor output. Brodmann area 6
The bilateral right middle frontal gyrus (Brodmann area 6), a premotor/supplementary motor region, has been implicated in multiple genetic and GWAS findings largely through imaging-genetics and disorder-based studies rather than region-specific SNP analyses. Variants in genes related to synaptic development and plasticity (e.g., BDNF, COMT, DISC1) have been associated with altered activation or structural metrics in BA6 during motor planning and executive tasks, and several schizophrenia, bipolar disorder, and major depression GWAS have highlighted risk loci whose carriers show abnormal gray matter volume or functional connectivity in right middle frontal/premotor cortex. Large-scale neuroimaging GWAS (e.g., ENIGMA and UK Biobank analyses) have identified common variants in genes involved in neurodevelopment (such as those near MAPT, CNTNAP2, and DCC) that correlate with frontal cortical thickness and surface area, encompassing BA6 and adjacent prefrontal regions, though effects are distributed rather than BA6-specific. Additionally, ADHD and autism spectrum disorder genetic risk scores have been linked to altered frontal motor/executive networks including BA6, and polygenic risk for cognitive traits (intelligence, educational attainment, working memory) shows imaging correlates in dorsal frontal and premotor cortex, suggesting that genetic influences on neurodevelopment and synaptic function contribute to structural and functional variability in this Talairach-defined area, but precise, atlas-level genetic associations for “Right Cerebrum.Frontal Lobe.Middle Frontal Gyrus.Gray Matter.Brodmann area 6” remain indirect and primarily inferred from broader frontal and premotor cortex findings.
Overview generated by GPT-4o (2026).
Region ID: 1024
Hemisphere: bilateral
Atlas: Talairach labels 2mm
Full Quality Version: Download MP4
Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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