The bilateral Right Cerebrum.Frontal Lobe.Superior Frontal Gyrus.Gray Matter corresponds to cortical tissue in the dorsal aspect of the frontal lobe, extending anteriorly along the medial and lateral surfaces of the hemisphere. Functionally, the superior frontal gyrus participates in higher-order executive processes, including working memory, attention control, decision-making, and aspects of self-awareness, as well as contributing to motor planning through connections with premotor and supplementary motor areas. It is involved in the regulation of voluntary behavior and the integration of cognitive and motor information, with bilateral engagement supporting complex goal-directed actions. Although there is no dedicated Wikipedia page for the Talairach-specified gray matter subdivision, it is part of the broader Superior frontal gyrus.
The bilateral Right Cerebrum.Frontal Lobe.Superior Frontal Gyrus.Gray Matter region, as defined in the Talairach labels 2 mm atlas, overlaps broadly with dorsomedial and superior lateral prefrontal cortex, and genetic associations are typically reported at this broader regional level rather than with this specific atlas label. GWAS and imaging-genetics studies have repeatedly implicated this frontal territory in polygenic influences on cortical thickness and surface area, including variants in genes involved in neurodevelopment (e.g., MAPT region on 17q21, CNTNAP2, and synaptic or axon-guidance genes) and large-scale polygenic scores for educational attainment and general cognitive ability, which often show positive associations with superior frontal morphology and activation. This region is also part of networks where risk variants for schizophrenia and bipolar disorder (e.g., CACNA1C, ZNF804A, and other loci identified in Psychiatric Genomics Consortium GWAS) are associated with altered gray matter volumes and functional connectivity, and it appears in studies linking APOE and other Alzheimer’s disease risk genes to frontal cortical atrophy and hypometabolism. Moreover, superior frontal gray matter characteristics have been associated with polygenic risk for major depression, ADHD, and autism spectrum disorder, as well as GWAS hits for personality traits (e.g., neuroticism) and behavioral measures such as impulsivity and risk-taking, reflecting that this frontal region is a convergence point where many distributed genetic influences on cognition, affect regulation, and executive control manifest in structural and functional variation.
Overview generated by GPT-4o (2026).
Region ID: 613
Hemisphere: bilateral
Atlas: Talairach labels 2mm
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Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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