Bilateral Right Cerebrum.Frontal Lobe.Superior Frontal Gyrus.Gray Matter.Brodmann area 10 corresponds to the anterior portion of the prefrontal cortex, often termed the frontopolar cortex. This region is heavily involved in high-level executive functions, including prospective memory, multi-tasking, complex planning, evaluation of future consequences, and integration of information over long time scales. It participates in abstract reasoning, social cognition, and the management of multiple goals, and is strongly interconnected with other prefrontal areas as well as limbic and parietal regions, supporting its role in cognitive control and decision making. Cytoarchitectonically, Brodmann area 10 is characterized by a granular cortical structure typical of association cortex and represents one of the most evolutionarily expanded regions in the human frontal lobe. There is no direct link for this exact Talairach composite label; a closely related structure is Brodmann area 10.
The bilateral right superior frontal gyrus (Brodmann area 10), a key node in the default mode and frontopolar networks, has been repeatedly implicated in genetic studies of brain structure and function, particularly through GWAS of cortical thickness, surface area, and gray matter volume. Large-scale imaging genetics consortia (e.g., ENIGMA, UK Biobank) have identified multiple common variants linked to superior frontal cortical morphology, including loci near genes involved in neurodevelopment, synaptic function, and axon guidance (such as variants in or near CENPW, TBR1, and other neurodevelopmental genes), with polygenic contributions shared across frontal regions. This area has shown heritable variation and genetic correlations with cognitive traits (working memory, general intelligence, executive function), personality dimensions (e.g., neuroticism, openness), and behavioral phenotypes like risk-taking and educational attainment. Genetic studies of psychiatric disorders, including schizophrenia, bipolar disorder, major depressive disorder, ADHD, and autism spectrum disorder, frequently report case–control differences and polygenic risk associations involving BA10 structure or activity, and some risk loci for these conditions exhibit pleiotropic effects on frontal cortical measures. Additionally, Alzheimer’s disease and other neurodegenerative GWAS have shown that polygenic risk scores are associated with accelerated atrophy or altered connectivity in superior frontal regions, suggesting that BA10 serves as a structural and functional convergence point where diverse genetic risk architectures manifest in higher-order cognition, affect regulation, and vulnerability to mental and neurodegenerative disorders.
Overview generated by GPT-4o (2026).
Region ID: 412
Hemisphere: bilateral
Atlas: Talairach labels 2mm
Full Quality Version: Download MP4
Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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