The bilateral Right Cerebrum.Frontal Lobe.Superior Frontal Gyrus.Gray Matter.Brodmann area 6 corresponds to a premotor and supplementary motor cortical region located in the dorsal frontal lobe anterior to the primary motor cortex (Brodmann area 4). This agranular cortical area is involved in the planning, sequencing, and preparation of voluntary movements, integration of sensory and motor information, and coordination of complex motor behaviors, including eye and limb movements. It contributes to motor imagery, motor learning, and aspects of executive control over action, and is structurally part of the superior frontal gyrus gray matter. There is no direct link for “Brodmann area 6” as a standalone article; a closely related article describing its broader anatomical and functional context is Premotor cortex.
The bilateral right superior frontal gyrus (Brodmann area 6), a premotor/supplementary motor region, has been implicated in multiple genetic and GWAS-based associations spanning motor function, cognition, and psychiatric risk. Imaging genetics studies using Talairach-based parcellations have linked variation in genes affecting synaptic plasticity and neurodevelopment (e.g., BDNF, COMT, CACNA1C, DISC1) to structural and functional measures in BA6, including gray matter volume, cortical thickness, and task-related activation. Large-scale GWAS of brain MRI phenotypes (such as ENIGMA and UK Biobank) have identified common variants in loci related to neuronal migration, axon guidance, and calcium channel signaling that associate with frontal cortical measures encompassing the superior frontal gyrus and premotor cortex, though often reported at lobar or broader regional levels rather than BA6 specifically. Genetic risk for disorders including schizophrenia, bipolar disorder, ADHD, major depressive disorder, and autism spectrum disorder has been repeatedly linked to alterations in BA6 structure and activation, with polygenic risk scores for these conditions correlating with frontal cortical morphology and connectivity patterns that involve this region. Additionally, GWAS of traits such as general cognitive ability, executive function, risk-taking, and motor skill learning show associations with genetic variants influencing frontal network development and integrity, indirectly implicating BA6 as a key node through which these variants exert their effects on behavior and disease vulnerability.
Overview generated by GPT-4o (2026).
Region ID: 1078
Hemisphere: bilateral
Atlas: Talairach labels 2mm
Full Quality Version: Download MP4
Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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