Bilateral Right Cerebrum.Frontal Lobe.Superior Frontal Gyrus.Gray Matter.Brodmann area 9 corresponds to a dorsal prefrontal cortical territory implicated in higher-order cognitive control and executive functions. Situated in the superior frontal gyrus, BA9 is involved in working memory, abstract reasoning, planning, and the regulation of goal-directed behavior, often integrating internal states and contextual information to guide decisions. Neuroimaging and lesion studies associate this region with cognitive flexibility, error monitoring, and aspects of social cognition such as theory of mind and moral judgment, reflecting its role in complex information processing and top–down modulation of other cortical and subcortical systems. There is no direct link for this exact composite label; a closely related structure is Brodmann area 9.
The bilateral right superior frontal gyrus (Brodmann area 9) gray matter has been implicated in multiple genetic and GWAS findings related to higher-order cognition, psychiatric risk, and brain morphology. Neuroimaging genetics studies, often using Talairach/Talairach-like parcellations, show that common variants influencing general intelligence and executive function—such as those in CHRM2, CNTNAP2, and genes involved in synaptic plasticity and neurodevelopment—are associated with structural measures and activation patterns in dorsolateral prefrontal regions encompassing BA9. Large-scale GWAS of cortical thickness and surface area (e.g., ENIGMA and other consortia) have identified loci in neurodevelopmental and cytoskeletal genes (including variants near HMGA2, KIAA0586, and others) that affect frontal lobe morphology, with superior frontal regions among the areas showing heritable variation. BA9 forms part of circuitry implicated in schizophrenia, bipolar disorder, major depressive disorder, ADHD, and autism spectrum conditions, and polygenic risk scores for these disorders often correlate with gray matter volume, cortical thickness, or functional activation in this region. Additionally, GWAS of traits such as cognitive performance, educational attainment, and risk-taking/impulsivity have linked associated variants to altered structure or connectivity in dorsolateral prefrontal cortex, including superior frontal gyrus, suggesting that genetic influences on frontal neurodevelopment and synaptic signaling contribute to individual differences in cognition, mood regulation, and behavioral control mediated by Brodmann area 9.
Overview generated by GPT-4o (2026).
Region ID: 903
Hemisphere: bilateral
Atlas: Talairach labels 2mm
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Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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