The bilateral Right Cerebrum.Frontal Lobe.Superior Frontal Gyrus.White Matter corresponds to the subcortical fiber tracts underlying the superior frontal gyrus in the frontal lobe of the right hemisphere, including association fibers that interconnect frontal regions and projection fibers that link these areas with subcortical and spinal structures. Functionally, this white matter supports higher-order executive processes, working memory, attentional control, and aspects of motor planning by enabling efficient communication between dorsolateral prefrontal cortex, premotor and supplementary motor areas, and broader cortical–subcortical networks. As part of the frontal white matter, it contributes to large-scale networks such as the frontoparietal control network and plays a role in goal-directed behavior and cognitive flexibility. There is no direct link for this specific white-matter subdivision; a related cortical structure is the Superior frontal gyrus.
Genetic associations involving the bilateral Right Cerebrum.Frontal Lobe.Superior Frontal Gyrus.White Matter, as defined in the Talairach labels 2mm Atlas, largely emerge from imaging genetics and GWAS of regional brain volume, cortical thickness, and white matter microstructure (e.g., fractional anisotropy) rather than this exact label alone. Large-scale GWAS of frontal white matter and superior frontal gyrus structure have implicated variants in genes involved in axon guidance, myelination, and synaptic development, including those near CNTNAP2, NRGN, MAG, and genes in the neuregulin and semaphorin pathways, which influence frontal connectivity. These structural measures in superior frontal white matter are repeatedly associated with polygenic risk for schizophrenia, bipolar disorder, major depressive disorder, autism spectrum disorder, and attention-deficit/hyperactivity disorder, consistent with the role of dorsomedial and superior frontal circuitry in cognitive control and self-referential processing. GWAS of brain-wide white matter integrity have also linked loci in or near APOE, CRHR1, and genes related to neuroinflammation and lipid metabolism to frontal white matter changes, connecting this region to risk for Alzheimer’s disease, vascular cognitive impairment, and age-related decline. Furthermore, genetic studies of traits such as intelligence, educational attainment, neuroticism, and risk-taking behavior show overlap between their polygenic architectures and the genetic determinants of superior frontal gyrus structure and connectivity, indicating that the frontal white matter in this region is a key substrate through which common genetic variants influence both psychiatric vulnerability and higher-order cognitive and personality traits.
Overview generated by GPT-4o (2026).
Region ID: 156
Hemisphere: bilateral
Atlas: Talairach labels 2mm
Full Quality Version: Download MP4
Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
This resource is licensed under CC0 1.0 Universal (Public Domain).