Bilateral Right Cerebrum.Limbic Lobe.Cingulate Gyrus.Gray Matter.Brodmann area 31 corresponds to a dorsal segment of the posterior cingulate cortex within the limbic lobe, situated along the medial aspect of the parietal region. This association cortex is implicated in high-level integrative functions, including internally directed cognition, attentional control, and aspects of autobiographical memory and self-referential processing, and forms part of the default mode network. Brodmann area 31 receives multimodal inputs from other cingulate fields, medial parietal cortex, and prefrontal regions, and projects widely to limbic and heteromodal association areas, supporting integration of emotional, cognitive, and visuospatial information. There is no direct link for Talairach “Right Cerebrum.Limbic Lobe.Cingulate Gyrus.Gray Matter.Brodmann area 31,” but it is part of Brodmann area 31.
Genetic associations involving the bilateral right Brodmann area 31 of the cingulate gyrus (limbic lobe gray matter) primarily emerge from imaging genetics and GWAS that link variation in this region’s structure and function to neuropsychiatric and cognitive traits. Common risk variants for major depressive disorder, anxiety, and bipolar disorder (e.g., in genes such as SLC6A4, BDNF, CACNA1C, and those enriched in synaptic and calcium-signaling pathways) have repeatedly been associated with altered volume, cortical thickness, or functional activation in posterior cingulate/BA31, particularly in networks supporting self-referential processing and emotion regulation. Large-scale brain MRI GWAS (e.g., ENIGMA and UK Biobank-based studies) have identified polygenic influences on cingulate cortex morphology and connectivity, implicating loci near genes involved in neurodevelopment (such as those regulating axon guidance and synaptogenesis) and overlapping with genetic risk for schizophrenia, Alzheimer’s disease, and general cognitive performance. BA31 lies within the default mode network, and polymorphisms associated with this network’s connectivity and task deactivation (including APOE and other AD-related loci) show links to posterior cingulate/BA31 hypometabolism and atrophy in Alzheimer’s disease and mild cognitive impairment. Additionally, genome-wide polygenic scores for traits such as neuroticism, rumination, and attentional control correlate with BA31-related functional measures, suggesting that the genetic architecture of mood and cognitive control partly manifests through structural and functional variation in this cingulate subregion.
Overview generated by GPT-4o (2026).
Region ID: 916
Hemisphere: bilateral
Atlas: Talairach labels 2mm
Full Quality Version: Download MP4
Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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